| 尾部悬吊对大鼠比目鱼肌肌梭电生理特性的影响 |
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| 引用本文： | 唐斌,樊小力,吴苏娣. 尾部悬吊对大鼠比目鱼肌肌梭电生理特性的影响[J]. 航天医学与医学工程, 2004, 17(1): 1-6 |
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| 作者姓名： | 唐斌 樊小力 吴苏娣 |
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| 作者单位： | 西安交通大学生理学教研室,陕西西安,710061;西安交通大学生理学教研室,陕西西安,710061;西安交通大学生理学教研室,陕西西安,710061 |
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| 基金项目： | supportedbytheNationalNaturalScienceFoun dation( 3 0 0 780 83 0 ) |
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| 摘 要： | 目的 观察模拟失重不同时期大鼠离体比目鱼肌肌梭电生理特性的改变。方法 采用大鼠尾悬吊法建立模拟失重模型。雌性大鼠随机分为模拟失重7d，14d组以及对照组。采用电生理学方法，观察模拟失重不同时期离体比目鱼肌肌梭的自发放电及对动-静式(ramp-and—hold)牵拉反应特性的改变。结果 模拟失重7d组大鼠肌梭自发放电频率明显降低，对动-静式牵拉反应性下降。14d组变化更为显著。结论 模拟失重可致肌梭的电生理特性发生明显的改变，并随模拟失重时间延长而加重。
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| 关 键 词： | 失重模拟 尾吊 比目鱼肌 肌梭 电生理学 |
Effects of Tail Suspension on Electrophysiological Characteristics of Muscle Spindles in Isolated Rat Soleus Muscle |
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| Abstract. Effects of Tail Suspension on Electrophysiological Characteristics of Muscle Spindles in Isolated Rat Soleus Muscle[J]. Space Medicine & Medical Engineering, 2004, 17(1): 1-6 |
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| Authors: | Abstract |
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| Affiliation: | Department of Physiology, Medical School of Xi'an Jiatong University, Xi'an. tang6876@yahoo.com.cn |
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| Abstract: | Objective To study changes in electrophysiological characteristics of muscle spindles induced by simulated weightlessness in isolated rats soleus. Method Weightlessness was simulated by tail suspension in female rats. Using electro physiological technique,the spontaneous discharge of muscle spindle and its response to ramp and hold stretch were observed in isolated soleus of 7 d,14 d tail suspended and control rats. Result Soleus muscle spindles of rat manifest a sharp decrease in spontaneous discharge frequency and the response to ramp and hold stretch after 7 d tail suspension. More significant changes were observed in rats after 14 d tail suspension. Conclusion Simulated weightlessness could induce time related changes in electrophysiological characteristics of soleus muscle spindles in rat. |
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| Keywords: | weightlessness simulation tail suspension soleus muscle spindles electrophysiology |
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