| 顺铂磁性纳米药物的安全性评价 |
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| 引用本文： | 陈帅君,谢民强,王蕾,龙镇,李仲汉,张宏征.顺铂磁性纳米药物的安全性评价[J].中国药房,2008,19(25):1941-1943. |
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| 作者姓名： | 陈帅君 谢民强 王蕾 龙镇 李仲汉 张宏征 |
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| 作者单位： | 1. 中山大学附属第三医院,广州市,510630;南方医科大学附属珠江医院,广州市,510282
2. 中山大学附属第三医院,广州市,510630 |
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| 基金项目： | 国家自然科学基金，广东省自然科学基金，广东省科技厅科技计划，广东省广州市科技计划 |
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| 摘 要： | 目的:初步评价顺铂磁性纳米药物的安全性。方法:以昆明种小鼠和豚鼠为实验动物,经尾静脉注射顺铂磁性纳米药物进行急性毒性实验和全身过敏性实验,并以顺铂注射液为对照,比较2种制剂的半数致死量(LD50)和过敏反应强度。结果:小鼠顺铂磁性纳米药物及顺铂注射液的LD50分别为15.618、18.087mg·kg-1,但未见前者对豚鼠有致敏作用,后者过敏反应为阳性。结论:顺铂经改性为磁性纳米药物后在一定剂量范围内毒性并没有明显增加,没有致敏作用。
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| 关 键 词： | 磁性纳米药物 顺铂 小鼠 豚鼠 安全性评价 |
Safety Assessment of Modified Cisplatinum Magnetic Nanomedicine |
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| CHEN Shuai-jun,XIE Min-qiang,WANG Lei,LONG Zhen,LI Zhong-han,ZHANG Hong-zheng.Safety Assessment of Modified Cisplatinum Magnetic Nanomedicine[J].China Pharmacy,2008,19(25):1941-1943. |
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| Authors: | CHEN Shuai-jun XIE Min-qiang WANG Lei LONG Zhen LI Zhong-han ZHANG Hong-zheng |
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| Institution: | CHEN Shuai-jun, XIE Min-qiang, WANG Lei, LONG Zhen, LI Zhong-han, ZHANG Hong-zheng(1.The Third Affiliated Hospital of Sun Yat- sen University, Guangzhou 510630, China;2.The Zhujiang Hospital Affiliated to Southern Medical University, Guangzhou 510282, China) |
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| Abstract: | OBJECTIVE： To assess the safety of the cisplatinum magnetic targeted nanomedicine （CMTN）. METHODS： Using Kunming mice and guinea pigs as experimental animals, the CMTN was injected into the animals＇ vena caudalis to observe the acute toxicity and the allergy characters. Cisplatinum injection （CI） was taken as the control, LD50 and intensity of allergic reaction of these two medicines were compared. RESULTS： The LD50 of CMTN and CI in mice were15.618 mg · kg^-1 and 18.087 mg · kg^-1, respectively. No anaphylaxis was noted in the guinea pigs receiving CMTN, but positive anaphylaxis was noted for CI. CONCLUSION： The experiment results showed that the toxicity of the modified CMTN wouldn＇t increase in a given range of concentration and it wouldn＇t lead to anaphylaxis. |
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| Keywords: | Magnetic nanomedicine Cisplatinum Mouce Guinear pig Safety assessment |
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