维生素D对毛细支气管炎患儿血清瘦素、T细胞亚群的影响及意义

目的：探讨维生素D对毛细支气管炎患儿瘦素、T细胞亚群的影响及意义。方法检测64例毛细支气管炎患儿血清维生素D、瘦素、T细胞亚群，其中30例维生素D检测结果偏低患儿，给予维生素D治疗，30 d复查，与对照组比较。结果64例毛细支气管炎患儿维生素D、CD3（%）、CD8（%）水平显著低于对照组（P〈0.05）,而瘦素、CD4（%）、CD4/CD8显著高于对照组（P〈0.05）；治疗30 d 时患儿维生素 D、CD3（%）、CD8（%）显著升高（P〈0.05），瘦素、CD4/CD8显著下降（P〈0.05），CD4虽有下降，但与治疗前差异无统计学意义（P〉0.05）。结论维生素D和瘦素参与了毛细支气管炎患儿免疫调节，对于毛细支气管炎患儿适量补充维生素D，能够改善患儿免疫状态。

The Effects and Significance of Vitamin D on Serum Leptin and T Lympho-cyte Subpoputation in Children with Bronchiolitis

Objective To investigate the effects and significance of oral vitamin D on serum leptin and T lymphocyte subpoputation in children with bronchiolitis. Methods The serum vitamin D level, leptin level and T lymphocyte subpoputation of 64 cases of in-fants with bronchiolitis were detected. Of whom, 30 cases who had lower vitamin D level were given the treatment of vitamin D. 30 days after the treatment, the vitamin D level, leptin level and T lymphocyte subpoputation of the patients were redetected, and the detection results were compared with those of the control group. Results The level of vitamin D, CD3 （%）, CD8 （%） of 64 infants with bronchiolitis was significantly lower than that of the control group （ P〈0.05）, but significantly higher in leptin, CD4 （%）, CD4/CD8（P〈0.05）. After 30 days of treatment, the level of vitamin D, CD3（%）, CD8（%） significantly elevated （P〈0.05） and the level of leptin, CD4/CD8 significantly decreased, compared with the beginning of the treatment （ P〈0.05）; although the level of CD4 de-creased, compared with that before the treatment, the difference was not statistically significant （ P〉0.05）. Conclusion Vitamin D and leptin take part in the immune regulation mechanism of bronchiolitis. For children with bronchiolitis, intaking moderate vita-min D can improve the immune state of these children.