hsCRP、VEGF及CysC的检测与2型糖尿病

目的：探讨2型糖尿病患者超敏C反应蛋白（hsCRP）、血管内皮生长因子（VEGF）及胱抑素C（Cys C）水平变化在糖尿病肾病发生、发展中的作用。方法采用速率散射比浊法、ELISA法及Olympus AU640分析仪分别检测血清hsCRP、VEGF及Cys C水平。结果2型糖尿病患者血清hsCRP、VEGF及Cys C水平高于对照组，糖尿病肾病组高于糖尿病无肾病组，糖尿病无肾病组高于正常对照组。2型糖尿病肾功能异常患者联合检测Cys C、hs-CRP阳性率与各单项比较有显著差异（ P＜0．05）。且治疗后糖尿病肾病患者血清hsCRP、VEGF及Cys C水平显著下降。结论hsCRP、VEGF及Cys C是糖尿病早期肾损害敏感指标，联合检测对及时准确地诊断糖尿病早期肾损害有重要的临床价值。

Detection of hsCRP,VEGF and Cys C and type II diabetic mellitus

Objective To investigate the significance of changes of serum hsCRP ,VEGF and Cys C levels in development of diabetic nephropathy in patients with type II diabetic mellitus .Methods Concentration of hsCRP was tested with rate neph-elometry,levels of VEGF with ELISA ,and Cys C with Olympus AU640.Results The concentrations of hsCRP ,VEGF and Cys C in the patient with type II diabetic nephropathy were higher than those in the patient with type II diabetic non -nephropathy and normal volunteers ,and the positive rate of combined measuring of CysC and hs-CRP was significantly higher than each sin-gle measuring and the concentrations of hsCRP ,VEGF and Cys C in the patient with type II diabetic nephropathy deceased sig-nificantly after effective therapy .Conclusion HsCRP,VEGF and Cys C may be used as sensitive parametres for diagnosing early renal injury in type II diabetic mellitus .Combined measuring is of more practical value .