依达拉奉对脑出血大鼠SOD及MDA的影响

目的：探讨依达拉奉对脑出血大鼠血肿周围脑组织SOD及MDA的影响。方法选SD大鼠90只，随机分成3组，每组30只，分别为假手术组、脑出血组及依达拉奉治疗组。将大鼠自体血注入尾状核制成脑出血模型；用黄嘌呤氧化法检测神经细胞SOD含量，改良的硫代巴比妥酸法测定MDA含量。结果脑出血组与假手术组比较SOD活性显著降低，而MDA含量增加（P＜0.05），依达拉奉治疗组与脑出血组相比，神经细胞SOD含量明显增高（P＜0.05），而MDA含量减低，差异有统计学意义（P＜0.05）。结论依达拉奉具有清除自由基作用，该作用与增加细胞SOD含量，抑制脂质过氧化过程有关。

The Effect of Edaravone on SOD and MDA of Rats with Cerebral Hemor-rhage

Objective To investigate the effect of edaravone on SOD and MDA in brain tissue around the hematoma of rats with cerebral hemorrhage. Methods 90 SD rats were chosen and randomly divided into 3 groups, control group, the cerebral hemor-rhage group and edaravone treatment group, respectively, each group of 30 rats. Cerebral hemorrhage model was made by injecting the autologous blood of rats into caudate nucleus. Xanthine oxidation method was used to detect the content of SOD in nerve cells, and improved thiobarbituric acid method was adopted to detect the MDA content. Results Compared with the control group, the SOD activity of the cerebral hemorrhage group decreased significantly, but MDA content increased （P〈0.05）; compared with the cerebral hemorrhage group, the SOD content in nerve cells of edaravone treatment group obviously increased, but MDA content de-creased, the difference was statistically significant （P〈0.05）. Conclusion Edaravone has the effect of scavenging free radicals, which is related to the increase of cellular SOD content and inhibition of the lipid peroxidation process.