Diurnal variation in the salivary melatonin responses to exercise: relation to exercise-mediated tachycardia |
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Authors: | K Marrin B Drust W Gregson C J Morris N Chester G Atkinson |
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Institution: | (1) Sport and Exercise Research Group, Edge Hill University, St. Helens Road, Ormskirk, Lancashire, L39 4QP, UK;(2) Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK;(3) Division of Sleep Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA |
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Abstract: | Salivary melatonin concentration is an established marker of human circadian rhythmicity. It is thought that melatonin is
relatively robust to the masking effects of exercise. Nevertheless, the extent and even the direction of exercise-related
change is unclear, possibly due to between-study differences in the time of day exercise is completed. Therefore, we aimed
to compare melatonin responses between morning and afternoon exercise, and explore the relationships between exercise-related
changes in melatonin and heart rate. At 08:00 and 17:00 hours, seven male subjects (mean ± SD age, 27 ± 5 years) completed
30 min of cycling at 70% peak oxygen uptake followed by 30 min of rest. Light intensity was maintained at ~150 lx. Salivary
melatonin (ELISA) and heart rate were measured at baseline, 15 min during exercise, immediately post-exercise and following
30 min recovery. Melatonin was ≈15 pg ml−1 higher in the morning trials compared with the afternoon (P = 0.030). The exercise-related increase in melatonin was more pronounced (P = 0.024) in the morning (11.1 ± 8.7 pg ml−1) than in the afternoon (5.1 ± 5.7 pg ml−1). The slope of the heart rate–melatonin relationship was significantly (P = 0.020) steeper in the morning (0.12 pg ml−1 beats−1 min−1) than in the afternoon (0.03 pg ml−1 beats−1 min−1). In conclusion, we report for the first time that the masking effect of moderate-intensity exercise on melatonin is approximately
twice as high in the morning than the afternoon. The much steeper relationship between heart rate and melatonin changes in
the morning raises the possibility that time of day alters the relationships between exercise-mediated sympathetic nervous
activity and melatonin secretion. |
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