CYP1A1基因多态性在子宫内膜异位症中的表达

目的　探讨CYP1A1基因多态性在子宫内膜异位症中的表达 ,了解其与子宫内膜异位症之间的关系。方法　采用PCR方法对子宫内膜异位症患者基因组DNA进行CYP1A1基因分型。结果　在 17例子宫内膜异位症标本中 ,CYP1A1I/I型频率为 0 .1176 ,CYP1A1V/V型频率为 0 .176 5 ,CYP1A1I/V型频率为 0 .70 5 9,含至少一个Val等位基因 (I/V +V/V )的频率为 0 .882 4 ,是I/I基因频率 (0 .1176 )的 7.5倍。结论　CYP1A1基因多态性中Val基因突变在子宫内膜异位症中占有很高的比例 ,提示该基因突变也许与子宫内膜异位症的发生之间有着密切联系。

The expressions of CYP1A1 genetic polymorphisms in endometriosis

Objective To investigate the expressions of CYP1A1 genetic polymorphisms in endometriosis, and to study the relationship between them.Methods CYP1A1 genetic polymorphisms were detected with method of Polymerase chain reaction (PCR) in 17 cases of endometriosis patents.Results The frequency of CYP1A1 I/I is 0.1176, and CYP1A1 V/V is 0.1765, then, CYP1A1 I/V is 0.7059. The frequency of CYP1A1 including no less then one Val gene mutation(I/V+V/V) is 0.8824. It's as 7.5 times high as the frequency of CYP1A1 I/I. Conclusion Genotype of Val gene mutation has a high proportion in endometriosis, and it maybe have a close relationship between endometriosis and CYP1A1 genetic polymorphisms.