| 纳米给药系统在难溶性药物制剂研究中的应用 |
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| 引用本文： | 连建豪,陈建明.纳米给药系统在难溶性药物制剂研究中的应用[J].中国新药与临床杂志,2012(8):441-446. |
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| 作者姓名： | 连建豪 陈建明 |
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| 作者单位： | 福建中医药大学;中国人民解放军第二军医大学药剂学教研室 |
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| 摘 要： | 近年来,难溶性药物给药系统一直是制剂学研究的重点和难点之一。纳米载体由于其良好的生物相容性及可装载大量难溶性药物等特点而被广泛应用于难溶性药物给药系统的研究,该类载体主要包括纳米粒、脂质体、纳米乳、聚合物胶束、纳米混悬剂等。本文结合近几年国内外文献报道,对纳米给药系统在难溶性药物制剂研究中的最新进展进行概述。
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| 关 键 词： | 纳米给药系统 难溶性药物 研究进展 |
Application of nano-drug delivery systems in pharmaceutical research for poorly water-soluble drugs |
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| LIAN Jian-hao,CHEN Jian-ming.Application of nano-drug delivery systems in pharmaceutical research for poorly water-soluble drugs[J].Chinese Journal of New Drugs and Clinical Remedies,2012(8):441-446. |
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| Authors: | LIAN Jian-hao CHEN Jian-ming |
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| Institution: | 1.Fujian University of Traditional Chinese Medicine,Fuzhou FUJIAN 350108,China;2.Pharmaceutical Science of the Second Military Medical University of PLA,SHANGHAI 200433,China) |
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| Abstract: | Recently,the delivery systems for poorly water-soluble drugs have been always being emphasis and difficulty in pharmaceutical research.Extensive approaches have been achieved in pharmaceutical researches for poorly water-soluble drugs.Nano-drug delivery systems,such as nanoparticles,liposomes,nanoemulsions, polymeric micelles,nanosuspensions,have been shown to be potentially excellent for high bioavailability and the capacity of loading large quantities of poorly water-soluble drugs.According to recent reports,this paper reviewed the applications of nano-drug delivery systems in pharmaceutical research for poorly water-soluble drugs. |
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| Keywords: | nano-drug delivery systems poorly water-soluable drugs research progress |
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