川崎病34例临床分析

目的:通过分析川崎病的流行病学特征及临床特点,为川崎病早期诊断及治疗提供临床依据.方法:对广州市越秀区儿童医院2007年至2011年诊治的34例川崎病患儿进行回顾性分析和总结.结果:(1)34例川崎病患儿中男23例,女11例,男女比例为2∶1;发病年龄以3岁以内婴幼儿为主(88.2％);发病季节以春、秋为主;不完全川崎病17例(50.0％).发热率100％,确诊前平均发热时间为6.5d,其他临床表现依次为口唇病变(83.4％)、球结膜充血(70.6％)、肢端硬肿或脱皮(64.7％)、皮疹(52.9％)、淋巴结肿大(35.3％).(2)心血管病变:合并冠状动脉病变者27例(79.4％),未见有冠状动脉瘤.(3)其他系统并发症:支气管炎、急性胃肠炎、口腔溃疡等.结论:川崎病具有多系统、多器官受累特点,冠状动脉病变发生与血沉(ESR)、C反应蛋白(CRP)、血小板(PLT)升高有关,不完全川崎病发病率高.

Kawasaki Disease:Clinical Analysis of 34 Cases

Objective: To investigate the epidemic features,clinical features of Kawasaki disease in the Children’s Hospital of Guangzhou,in order to promote early diagnosis and treatment.Methods: The clinical characteristics and treatment of 34 cases with Kawasaki disease from 2007 to 2011 were analyzed retrospectively and summarized.Results:(1)Clinical features: male to female ratio was 2∶1.The peak age of onset was 0~3 years(88.2%).The peak onset time was the Spring and Autumn.The 17 cases(50.0%) were incomplete KD.The 34 cases all had fever(100%).The average duration of fever before diagnosing was 6.5 days,83.4% had oral mucosa erythema and dry,fissured lips and/or strawberry tongue,70.6% had bilateral conjunctival congestion,64.7% had redness and/or swelling/or desquamation of the hands and feet,52.9% had rash,35.3% had cervical lymphadenopathy of at least 1.5 cm in diameter.(2) Coronary artery damage: coronary artery damage existed in 27 cases(79.4%),no one had coronary aneurysm formation.(3)Non-cardiovascular complications: bronchitis,acute gastroenteritis,canker sore,et al.Conclusions: KD could cause the breakdown of all kinds of systems.The occurrence of coronary artery is related to ESR,CRP,PLT.Incomplete KD has a high incidence.