| 人类免疫缺陷病毒感染者重叠输血传播病毒感染的临床研究 |
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| 引用本文： | 欧强,周坚.人类免疫缺陷病毒感染者重叠输血传播病毒感染的临床研究[J].肝脏,2008,13(4):292-294. |
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| 作者姓名： | 欧强 周坚 |
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| 作者单位： | 上海复旦大学附属公共卫生临床中心,201508 |
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| 基金项目： | 复旦大学上海医学院青年科研基金 |
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| 摘 要： | 目的 了解中国地区人类免疫缺陷病毒（HIV-1）感染者重叠输血传播病毒（TTV）感染的流行情况，并探讨重叠感染TTV对CD4^＋T淋巴细胞计数及HIVRNA病毒载量的影响。方法收集55例HIV-1感染者的血浆标本，采用荧光定量PCR法检测TTVDNA，流式细胞法检测T淋巴细胞亚群，bDNA方法检测HIVRNA。结果HIV感染者中TTVDNA检出率及TTVDNA滴度明显高于健康对照组（P〈0．05）。HIV／TTV重叠感染者CD4^＋T淋巴细胞计数低于单纯HIV感染者。HIVRNA病毒载量高于单纯HIV感染者，两组比较差异有统计学意义（P〈0．05）。结论中国地区HIV感染者易重叠感染TTV，且滴度较高。重叠感染TTV可能导致细胞免疫功能进一步下降，加快病毒复制，促进HIV病程的进展。
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| 关 键 词： | 人类免疫缺陷病毒 输血传播病毒 临床研究 |
The clinical research on patients with superinfection of HIV-1 and TTV |
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| OU Qiang,ZHOU Jian.The clinical research on patients with superinfection of HIV-1 and TTV[J].Chinese Hepatology,2008,13(4):292-294. |
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| Authors: | OU Qiang ZHOU Jian |
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| Institution: | OU Qiang,ZHOU Jian. Public Health Clinical Center Affiliated to Fudan University,Shanghai 201508,China |
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| Abstract: | Objective To investigate the prevalence of superinfection of HIV-1 and TTV in China and discuss the influence of TTV co-infection in the count of CD4+T cell and the load of HIV RNA.Methods The plasm of 55 cases of HIV/AIDS patients was collected.TTV DNA was detected by real-time quantitative PCR.T lymphocyte cell subsets were detected by flow cytometry.HIV RNA was detected by bDNA.Results The positive rate of TTV and the titer of TTV DNA in HIV/AIDS patients were much higher than those in normal control gro... |
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| Keywords: | HIV TTV Clinical research |
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