| 系统性红斑狼疮患儿PD-1分子的表达 |
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| 引用本文： | 夏敏,薛海燕,曹兰芳.系统性红斑狼疮患儿PD-1分子的表达[J].临床儿科杂志,2008,26(11):959-961. |
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| 作者姓名： | 夏敏 薛海燕 曹兰芳 |
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| 作者单位： | 上海交通大学医学院附属仁济医院儿科,上海,200001 |
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| 基金项目： | 上海市科学技术委员会科研计划项目(No.044119716) |
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| 摘 要： | 目的 研究PD-1分子的表达与系统性红斑狼疮（SLE）的发病机制及病情的关系。方法 应用流式细胞仪检测各期SLE患儿（活动期、缓解期）外周血CD3^＋、CD4^＋、CD8^＋T细胞上PD-1分子的表达。结果 在各期SLE患儿中外周血CD3^＋、CD4^＋、CD8^＋淋巴细胞上PD-1分子的表达均明显高于正常对照（P〈0.05）。结论 在系统性红斑狼疮患儿外周血淋巴细胞上PD-1分子表达明显高于正常,各组SLE患儿存在B淋巴细胞的异常增殖,推测 PD-1通路在SLE的免疫病理中发挥重要作用。
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| 关 键 词： | PD-1分子 系统性红斑狼疮 儿童 |
Expression of PD-1 on peripheral blood lymphocyte in systemic lupus erythematosus patients |
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| XIA Min,XUE Hai-yan,CAO Lan-fang.Expression of PD-1 on peripheral blood lymphocyte in systemic lupus erythematosus patients[J].The Journal of Clinical Pediatrics,2008,26(11):959-961. |
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| Authors: | XIA Min XUE Hai-yan CAO Lan-fang |
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| Abstract: | Objectives To investigate the role of PD-1 in pathogenesis of patients with systemic lupus erythema-tosus(SLE) .Methods Flow cytometry was used to determine expression of PD-1 on peripheral blood lymphocyte in SLE patients(include active stage group and catabasis group).Results Expression of PD-1 on peripheral blood lympho-cyte in both SLE patient groups are significantly higher than that in health control(P < 0.05).Conclusions Expression of PD-1 on peripheral blood lymphocyte in SLE patients are obviously ... |
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| Keywords: | PD-1 systemic lupus erythematosus children |
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