Intrinsic non-hub connectivity predicts human inter-temporal decision-making

Inter-temporal decision-making is ubiquitous in daily life and has been considered as a critical characteristic associated with an individual’s success. Such decisions require us to tradeoff between short-term and long-term benefits. Prior studies have indicated that inter-temporal decision involves various brain regions that tend to occupy the central hubs. However, it is unclear whether the functional connectivities among hub as well as non-hub regions can predict discounting behaviors. Here, we combined with graph-theoretical algorithm and multivariate pattern analysis to explore whether voxel-wise functional connectivity strength in the whole brain could predict discounting rates (indexed as logk, based on the adaptive delay-discounting task) in a relatively large sample (n = 429) of young adults. Results revealed that short- and long-distance as well as all-range non-hub functional connectivity strength in the limbic system (i.e., medial orbitofrontal cortex and parahippocampus) were inversely associated with discounting rates. Furthermore, these results were robust and did not appear to be due to potential confounding factors. Above weight-based degree metric is commonly indicative of the communication pattern of local and global parallel information processing, and it therefore provides novel insights into the neural mechanisms underlying inter-temporal decision-making from the perspective of human brain topological organizations.