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Antidiabetic activity of aqueous leaf extract of Atriplex halimus L. (Chenopodiaceae) in streptozotocin-induced diabetic rats
Authors:Ilyas Chikhi  Hocine Allali  Mohamed El Amine Dib  Houria Medjdoub  Boufeldja Tabti
Institution:1.Laboratory of Natural and Bioactive Products (LASNABIO), Department of Chemistry, Faculty of Sciences, Abou Bekr Belkaïd University, BP119 Tlemcen 13000, Algeria;2.Department of Biology, Faculty of Sciences of Nature and Life, University of Mascara, Algeria;University of Mohamed, 1er Oujda, Bd. Med VI, B.P. 717, Oujda 60000, Morocco., Tel: +212 76 88 99 49, Fax: +212 36 50 06 03, E-mail:
Abstract:

Objective

To investigate the antidiabetic effect of A. halimus leaf in streptozotocin-induced diabetic rats.

Methods

The aqueous extract of the plant leaf was tested for its efficacy in streptozotocin-induced diabetic rats. The extract was evaluated for its acute and short term general toxicity in male mice and for its antihyperglycemic activity using glucose tolerance test in rats. The aqueous extract was subjected to phytochemical screening and determination of total phenolic contents.

Results

The statistical data indicated the significant increase in the body weight and decrease in the blood glucose and hepatic levels. The total protein level was significantly increased when treated with the extract.

Conclusions

These results suggest that the aqueous leaf extract of A. halimus has beneficial effects in reducing the elevated blood glucose level and hepatic levels in streptozotocin-induced diabetic rats.
Keywords:Atriplex halimus L    Chenopodiaceae  Aqueous extract  Antidiabetic  Streptozotocin
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