Co-occurrence of type 1 diabetes mellitus and celiac disease |
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Authors: | Amit Akirov Orit Pinhas-Hamiel |
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Affiliation: | Amit Akirov, Beilinson Campus, Rabin Medical Center, Petach-Tikva 49100, IsraelAmit Akirov, Orit Pinhas-Hamiel, Sackler School of Medicine, Tel-Aviv University, Tel Aviv 69978, IsraelOrit Pinhas-Hamiel, Pediatric Endocrine and Diabetes Unit, Safra Children’s Hospital, Sheba Medical Center, Ramat-Gan 52621, Israel |
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Abstract: | The co-occurrence of celiac disease(CD) and type 1 diabetes(T1DM) has been reported as 5-7 times more prevalent than CD alone.The clinical presentation and natural history of CD in patients with T1 DM may vary considerably.Less than 10% of patients with T1 DM and CD show gastrointestinal symptoms.Therefore,experts support screening for CD in T1 DM patients,though there is no consensus as to the recommended frequency of screening.When stratified by time since CD diagnosis,longer follow-up and coexistence of CD are associated with significant increased risk of diabetic associated morbidity and mortality.Early CD diagnosis and treatment with a gluten-free diet are essential. |
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Keywords: | Type 1 diabetes mellitus Celiac disease Glycemic control Gluten free diet Pediatrics |
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