Role of antiviral therapy in the natural history of hepatitis B virus-related chronic liver disease |
| |
Authors: | Francesco Paolo Russo Kryssia Rodrí guez-Castro Laura Scribano Giorgia Gottardo Veronica Vanin Fabio Farinati |
| |
Affiliation: | Francesco Paolo Russo, Kryssia Rodríguez-Castro, Gastroenterology/Multiviseral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, 35128 PD Padua, ItalyLaura Scribano, Giorgia Gottardo, Veronica Vanin, Fabio Farinati, Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, 35128 PD Padua, Italy |
| |
Abstract: | Hepatitis B virus(HBV) infection is a dynamic state ofinteractions among HBV, hepatocytes, and the host immune system. Natural history studies of chronic hepatitis B(CHB) infection have shown an association between active viral replication and adverse clinical outcomes such as cirrhosis and hepatocellular carcinoma. The goal of therapy for CHB is to improve quality of life and survival by preventing progression of the disease to cirrhosis, decompensation, end-stage liver disease, hepatocellular carcinoma(HCC) and death. This goal can be achieved if HBV replication is suppressed in a sustained manner. The accompanying reduction in histological activity of CHB lessens the risk of cirrhosis and of HCC, particularly in non-cirrhotic patients. However, CHB infection cannot be completely eradicated, due to the persistence of covalently closed circular DNA in the nucleus of infected hepatocytes, which may explain HBV reactivation. Moreover, the integration of the HBV genome into the host genome may favour oncogenesis, development of HCC and may also contribute to HBV reactivation. |
| |
Keywords: | Hepatocellular carcinoma Nucleos(t)ide analogues Liver fibrosis Pegylated interferon Cirrhosis |
本文献已被 CNKI 等数据库收录! |
| 点击此处可从《World journal of hepatology》浏览原始摘要信息 |
|