Therapeutic and clinical aspects of portal vein thrombosis in patients with cirrhosis |
| |
Authors: | Massimo Primignani Giulia Tosetti Vincenzo La Mura |
| |
Affiliation: | Massimo Primignani, Giulia Tosetti, U.O. Gastroenterologia ed Epatologia, IRCCS-Ca’ Granda, Ospedale Maggiore Policlinico, 20122 Milano, ItalyVincenzo La Mura, U.O. Medicina Interna, IRCCS-San Donato, Dipartimento di Scienze Biomediche per la Salute, Università degli studi di Milano, 20097 Milan, Italy |
| |
Abstract: | Portal vein thrombosis(PVT) is a frequent complication in cirrhosis, particularly in advanced stages of the disease. As for general venous thromboembolism, risk factors for PVT are slow blood flow, vessel wall damage and hypercoagulability, all features of advanced cirrhosis. Actually, the old dogma of a hemorrhagic tendency in cirrhosis has been challenged by new laboratory tools and the clinical evidence that venous thrombosis also occurs in cirrhosis. The impaired hepatic synthesis of both pro- and anticoagulants leads to a rebalanced hemostasis, more liable to be tipped towards thrombosis or even bleeding. Conventional anticoagulant drugs(low molecular weight heparin or vitamin K antagonists) may be used in cirrhosis patients with PVT, particularly in those eligible for liver transplantation, to prevent thrombosis progression thus permitting/facilitating liver transplant. However, several doubts exist on the level of anticoagulation achieved as estimated by coagulation tests, on the efficacy of treatment monitoring and on the correct timing for discontinuation in non-transplant candidates, while in transplant candidates there is expert consensus on continuing anticoagulation until transplantation. The recent introduction of direct acting oral anticoagulant drugs(DOACs) in other clinical settings generates much interest on their possible application in patients with cirrhosis and PVT. However, DOACs were not evaluated yet in patients with liver disease and cannot be recommended for the present time. |
| |
Keywords: | Portal vein thrombosis Coagulopathy Hypercoagulopathy Direct acting oral anticoagulant drugs Cirrhosis |
本文献已被 CNKI 等数据库收录! |
| 点击此处可从《World journal of hepatology》浏览原始摘要信息 |
|