Total n-3 polyunsaturated fatty acid intake is inversely associated with serum C-reactive protein in young Japanese women |
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| Authors: | Kentaro Murakami Satoshi Sasaki Yoshiko Takahashi Kazuhiro Uenishi Mitsuyo Yamasaki Hitomi Hayabuchi Toshinao Goda Jun Oka Keiko Baba Kazuko Ohki Kanako Muramatsu Yoshiko Sugiyama |
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| Institution: | 1. Nutritional Epidemiology Program, National Institutes of Health and Nutrition, Tokyo, Japan;2. Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Tokyo, Japan;3. Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Tokyo, Japan;4. Department of Health and Nutrition, School of Home Economics, Wayo Women''s University, Chiba, Japan;5. Laboratory of Physiological Nutrition, Kagawa Nutrition University, Saitama, Japan;6. Department of Health and Nutrition Science, Faculty of Health and Social Welfare Science, Nishikyushu University, Saga, Japan;g Department of Human Environmental Science, Fukuoka Women''s University, Fukuoka, Japan;h Department of Nutrition, School of Food and Nutritional Sciences and COE21, University of Shizuoka, Shizuoka, Japan;i Department of Food and Nutrition, Faculty of Home Economics, Tokyo Kasei University, Tokyo, Japan;j Department of Nutrition, Mie Chukyo University Junior College, Mie, Japan;k Graduate School of Science for Living System, Showa Women''s University, Tokyo, Japan;l Course of Food and Nutrition, Department of Human Life Environments, Niigata Women''s College, Niigata, Japan;m Department of Nutrition Management, Faculty of Health and Nutrition, Minamikyushu University, Miyazaki, Japan |
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| Abstract: | Little is known about the relation of dietary factors to circulating C-reactive protein (CRP) concentrations in young adults and non-Western populations. We cross-sectionally examined associations between dietary intake and serum CRP concentrations in young Japanese women. The subjects were 443 female Japanese dietetic students aged 18 to 22 years. Dietary intake was assessed with a validated, self-administered, comprehensive, diet history questionnaire. Serum CRP concentrations were measured by highly sensitive nephelometry. The prevalence of elevated CRP (≥1 mg/L) was 5.6%. After adjustment for possible confounding factors including body mass index, a significant inverse association was seen between total n-3 polyunsaturated fatty acid intake and elevated CRP. The multivariate adjusted odds ratios of elevated CRP for women with intake below and above the median (1.1% of energy) were 1.00 and 0.33 (95% confidence interval, 0.13-0.82; P = .02), respectively. Intake of eicosapentaenoic acid + docosahexaenoic acid and α-linolenic acid was not associated with elevated CRP concentrations (P = .62 and P = .27, respectively). Vitamin C intake was independently inversely associated with elevated CRP, although the association was nonsignificant (P = .10). No clear associations were observed for other dietary factors examined including total fat, saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, total dietary fiber, soluble dietary fiber, insoluble dietary fiber, and magnesium; fruits, vegetables, and fish and shellfish; and dietary glycemic load (P = .27 to P = .99). In conclusion, total n-3 polyunsaturated fatty acid intake showed an independent inverse association with elevated serum CRP concentration in a group of young Japanese women. |
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| Keywords: | n-3 polyunsaturated fatty acid C-reactive protein Diet Young Japanese women EpidemiologyAbbreviations: ALA α -linolenic acid BMI body mass index CRP C-reactive protein DHA docosahexaenoic acid DHQ diet history questionnaire EPA eicosapentaenoic acid MUFA monounsaturated fatty acid PUFA polyunsaturated fatty acid SFA saturated fatty acid |
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