胃癌患者细胞间黏附分子-1表达意义的研究

目的 :研究胃癌瘤体细胞间黏附分子 - 1(intercellularadhesionmolecule- 1,ICAM - 1)的表达与胃癌临床病理特征及其侵袭转移的关系。方法 :采用免疫组化技术 (S -P法 )对 6 0例胃癌及 15例远癌胃组织标本中ICAM - 1进行检测 ,分析ICAM - 1的表达与胃癌临床病理之间的关系。结果 :胃癌和远癌胃组织中ICAM - 1的阳性表达率分别为70 % (42 / 6 0 )和 2 0 % (3/ 15 ) ,两者之间差异有显著性 (P <0 .0 1) ,组织ICAM - 1表达水平与胃癌淋巴结转移、TNM分期密切相关。结论 :检测胃癌组织ICAM - 1的表达水平对评估淋巴结转移程度、TNM分期及胃癌侵袭深度有较大意义 ,ICAM - 1可能是反映胃癌侵袭转移潜能的一个有效生物学指标

Expression of Intercellular Adhesion Molecule- 1 in Gastric Cancer and Its Clinical Significance

Objective:This study was to determine the expression of ICAM-1(intercellular adhesion molecule-1) in patients with gastric cancer and to elucidate the relation of its level with clinical characteristics and metastasis of gastric cancer.Methods:Immunohistochemical method was used to detect ICAM-1 expression in 60 patients with gastric cancer and in 15 cases of gastric tissue distal to cancer cell .Results:The positive expression rates of ICAM-1 in gastriccancer and gastric tissue distal to cancer cell were 70%(42/60) and 20%(3/15)respectively, with significant difference (P<0.01), The intensity of ICAM-1 expression in tissue of gastric cancer was correlated with lymph node metastasis and TNM stage.Conclusions:Examination of ICAM-1 in gastric cancer helps evaluation intensity of lymph node metastasis,TNM stage and prognosis of patients. ICAM-1 might be valuable markers in assessing invasion and metastasis potential of gastric carcinoma.