| 肾移植术后患者骨代谢的改变 |
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| 引用本文： | 米华,邓耀良,吴闯,李盛宽,刘德云. 肾移植术后患者骨代谢的改变[J]. 临床泌尿外科杂志, 2005, 20(8): 455-457 |
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| 作者姓名： | 米华 邓耀良 吴闯 李盛宽 刘德云 |
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| 作者单位： | 1. 广西医科大学第一附属医院器官移植中心,南宁,530021
2. 广西医科大学第一附属医院药剂科 |
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| 摘 要： | 目的:研究肾移植术后患者骨代谢生化指标的改变.方法:采用竞争性放射免疫分析法测定30例肾移植患者和25例健康献血者的血清骨代谢生化指标:骨钙素(BGP)、降钙素(CT)、甲状旁腺激素(PTH)和25羟基维生素D(25-OH-D)、Ⅰ型胶原羧基端交联肽原(ICTP)和Ⅰ型前胶原氨基端伸展肽(PINP)水平.结果:肾移植术后患者的BGP、PINP和ICTP水平明显高于正常对照组(P＜0.01),但两组的CT、25-OH-D和PTH水平差异无统计学意义(P＞0.05).结论:肾移植术后患者出现明显的骨代谢紊乱,主要表现为血清成骨细胞活性增强,同时伴有破骨细胞功能增强,骨转换活跃,其发病机制可能主要与术后长期使用免疫抑制剂有关.
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| 关 键 词： | 骨生化指标 肾移植 |
| 文章编号： | 1001-1420(2005)08-0455-03 |
| 收稿时间： | 2004-12-29 |
| 修稿时间： | 2004-12-29 |
Variation of biochemical bone markers in renal transplant recipients |
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| Mi Hua,DENG Yaoliang,WU Chuang,LI Shengkuan,Liu Deyun. Variation of biochemical bone markers in renal transplant recipients[J]. Journal of Clinical Urology, 2005, 20(8): 455-457 |
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| Authors: | Mi Hua DENG Yaoliang WU Chuang LI Shengkuan Liu Deyun |
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| Abstract: | Objective:To evaluate the variations of serum biochemical bone markers in renal transplant recipients.Methods:Serum level of Osteocalcin (BGP), Calcitonin(CT), Parathyroid hormone(PTH), 25-hydroxyvitamin D(25-OH-D), Cross-linked carboxyterminal telopeptide of type I collagen (ICTP), Aminoterminal propeptide of type I procollagen (PINP) were measured by radioimmunoassay in 30 renal transplant recipients and 25 healthy people.Results:The serum level of BGP, PINP and ICTP were significantly increased in the renal transplant recipients (P<(0.01)),but CT, 25-OH-D and PTH level were not significantly different in renal transplant recipients compared with control group(P>(0.05)).Conclusions:Markers of bone turnover were increased in renal transplant recipients, which might be related to the immunosuppression therapy. |
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| Keywords: | Biochemical hone marker Renal transplantation |
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