坏疽性脓皮病19例临床分析

目的:提高对坏疽性脓皮病(PG)的认识,探讨其最有效的治疗方法。方法:对1994—2004年在我科住院的19例PG患者的临床资料进行回顾性分析。结果:该病发病年龄以45岁以上居多;PG除有皮肤损害外,还可累及其他器官。约42.1%的患者并发有系统性疾病,其中以并发糖尿病居多。实验室检查结果和组织病理改变无特异性。结论:PG是一种少见的皮肤病,主要根据其临床特点诊断。目前,糖皮质激素是控制PG最有效的药物,亦可联合应用免疫抑制剂、磺胺类、米诺环素等药物,局部治疗有利于皮损愈合。

Analysis of 19 cases with pyoderma gangrenosum

Objective:To improve the recognition of clinical feature of pyoderma gangrenosum(PG)and explore the existing treatment.Methods:The clinical and laboratory data of 19 PG in-patients from 1994 to 2004 were analyzed retrospectively.Results:Most of PG patients were beyond 45 years old.Aside from the recurrent skin lesions,other organs can also be involved in this disease.About 42.1% of PG patients suffered from one or several other diseases,and a complication with diabetes mellitus was found the most(in 5 patients).There were no specific laboratory findings or dermatopathological results.Conclusions:PG is a rare disease and its diagnosis is established from typical clinical presentation.Corticosteroids is the most effective medicine to control PG,while other drugs such as immunosuppressive agents,sulfa drugs and minocycline,are also combined.Topical therapies can be helpful to cure skin lesions.