Malignant Myoepithelioma of the Larynx with Massive Metastatic Spread to the Liver: An Ultrastructural and Immunocytochemical Study |
| |
Authors: | Roberto Ibrahim Dennis J. Bird Marcel W. Sieler |
| |
Affiliation: | a Department of Laboratory Service, Department of Veterans Affairs, Medical Center, West Roxburyb Harvard Medical School, Boston, Massachusetts |
| |
Abstract: | A malignant myoepithelioma arising in the submucosal glands of the larynx of a 71-year-old man is reported. The patient presented with a neck mass and massive metastatic involvement of the liver. Light microscopy of a liver biopsy specimen and fine-needle aspiration sample of the neck mass revealed a poorly differentiated carcinoma. Electron microscopic study of a second liver biopsy specimen demonstrated unequivocal features of myoepithelial differentiation; this was further confirmed by the strong cytokeratin and S-100 protein positivity and carcinoembryonic antigen negativity of the tumor cells. Myoepitheliomas are rare tumors, and most reported cases have been benign or of low-grade malignancy. The present case is unique because of its mode of presentation and fulminant course. It also underscores the usefulness of electron microscopy as a diagnostic modality in the work-up of metastatic lesions. |
| |
Keywords: | immunocytochemistry larynx malignant myoepithelioma transmission electron microscopy |
本文献已被 InformaWorld 等数据库收录! |