Distinguishing patterns in the dynamics of long-term medication use by Markov analysis: beyond persistence |
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| Authors: | Tanja T Menckeberg Svetlana V Belitser Marcel L Bouvy Madelon Bracke Jan-Willem J Lammers Jan AM Raaijmakers Hubert GM Leufkens |
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| Affiliation: | (1) Division of Pharmacoepidemiology & Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht, The Netherlands;(2) SIR Institute for Pharmacy Practice and Policy, Leiden, The Netherlands;(3) Department of Pulmonary Diseases, Heart Lung Centre Utrecht, University Medical Centre, Utrecht, The Netherlands |
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| Abstract: | Background In order to accurately distinguish gaps of varying length in drug treatment for chronic conditions from discontinuation without resuming therapy, short-term observation does not suffice. Thus, the use of inhalation corticosteroids (ICS) in the long-term, during a ten-year period is investigated. To describe medication use as a continuum, taking into account the timeliness and consistency of refilling, a Markov model is proposed. |
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