脑星形细胞瘤MRI表现与血管内皮生长因子表达的关系

目的:探讨脑星形细胞瘤血管内皮生长因子的表达与MRI表现的关系.材料和方法:收集手术病理证实的脑星形细胞瘤42例,分析其M RI表现.采用免疫组织化学技术染色VEGF,并分析其表达程度与M RI表现的关系.结果:星形细胞瘤的VEGF表达与其病理分级、患者复发密切相关.星形细胞瘤MRI信号的不均匀性、边界清楚与否、瘤周水肿范围、占位效应及增强程度与VEGF表达明显相关,但星形细胞瘤的大小、部位与VEGF表达无明显相关性.结论:星形细胞瘤的MRI征象能反映星形细胞瘤的VEGF表达.术前分析星形细胞瘤的MRI征象与VEGF表达的关系,能更好地指导临床治疗方案的选择和评估患者的预后.

Correlation Study of MRI Features with Vascular Endothelial Growth Factor Expression in Brain Astrocytoma

Purpose: To study the correlation of MRI features with vascular endothelial g rowth factor(VEGF)expression in brain astrocytoma.Materials and Methods: MRI fin dings of 42 cases of astrocytoma proved surgically and pathologically were analy zed retrospectively.VEGF was stained with immunohistochemial method, and the res ults were compared with MRI features.Results: VEGF expression correlated well wi th pathological grade and relapse of patient with astrocytoma. Heterogeneous sig nal intensity, ill-defined margin, degree of peritumor edema, degree of contra st enhancement had positive correlation with VEGF expression.But the tumor locat ion and size did not correlated with VEGF expression. Conclusion: MRI features c an evaluate VEGF expression in astrocytoma. Preoperative analysis of correlation between MRI features and VEGF expression is helpful to guide the treatment and evaluate prognosis of patients with astrocytoma.