Expression of the CD4 molecule on acute nonlymphocytic leukemia (ANLL) cell lines |
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Authors: | S Neudorf C DeLaat M Jones |
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Institution: | Division of Hematology/Oncology, Children's Hospital Research Foundation, Cincinnati, OH 45229. |
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Abstract: | Mature and immature monocytes express the CD4 molecule similar to that expressed on lymphocytes. Since monocytes and cells of myeloid lineage are derived from a common progenitor, we studied a panel of nine myeloid leukemia cell lines for the expression of the CD4 molecule. We found that six of nine myeloid leukemia cell lines (U937, KG1-B, HL-60, THP-1, HEL 92.1.7, KMOE) expressed CD4, the exceptions being the erythroleukemia line K562, myeloblast line KG1-REV, and megakaryocytic line, CHRF-288. SDS-PAGE analysis of HL-60 cells immunoprecipitated with OKT4 showed the presence of a 55 kd molecule similar in weight to that seen on lymphocytes. These data suggest that some myeloid progenitor cells express the CD4 molecule and that the CD4 may have a broader distribution within hematopoietic cells. |
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Keywords: | AIDS CD4 acute nonlymphocytic leukemia |
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