| 更年安胶囊对去势雌性小鼠的治疗作用 |
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| 引用本文： | 王蕊,傅强,厉璐帆,马海滨,马世平. 更年安胶囊对去势雌性小鼠的治疗作用[J]. 药学与临床研究, 2010, 18(3): 247-249 |
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| 作者姓名： | 王蕊 傅强 厉璐帆 马海滨 马世平 |
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| 作者单位： | 中国药科大学中药药理教研室,南京,210009 |
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| 摘 要： | 目的:观察更年安胶囊对去势雌性小鼠的治疗作用.方法:小鼠摘除卵巢,造成去势小鼠,给药后观察药物对小鼠的自主活动、睡眠、学习记忆能力的影响;检测小鼠血清中SOD、GSH-PX活力及MDA含量;检测血清中血脂TC、TG、HDL、LDL含量.结果:与模型组相比,更年安胶囊低、中、高剂量组均能显著增加小鼠入眠只数,显著提高小鼠的学习记忆能力,显著增加小鼠血清中SOD、GSH-PX活力、降低MDA含量,显著降低小鼠血清中TC、TG、LDL含量.结论:更年安胶囊对去势雌性小鼠具有一定疗效,为临床治疗妇女更年期综合征提供了实验依据.
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| 关 键 词： | 更年安胶囊 更年期综合征 镇静催眠 学习记忆 抗自由基 血脂 |
| 收稿时间： | 2010-03-09 |
| 修稿时间： | 2010-03-22 |
Effect of Gengnianan Capsule to the Ovariectomy Female Mice |
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| WANG Rui,FU Qiang,LI Lu-fan,MA Hai-bin and MA Shi-ping. Effect of Gengnianan Capsule to the Ovariectomy Female Mice[J]. Pharmacertical and Clinical Research, 2010, 18(3): 247-249 |
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| Authors: | WANG Rui FU Qiang LI Lu-fan MA Hai-bin MA Shi-ping |
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| Affiliation: | Department of Pharmacology of the Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China;Department of Pharmacology of the Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China;Department of Pharmacology of the Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China;Department of Pharmacology of the Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China;Department of Pharmacology of the Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China |
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| Abstract: | Objective: Use the ovariectomy mice as model to study the therapeutic effect of Gengnianan capsules on menopausal syndrome. Methods: The ovaries of mice were removed to form menopausal syndrome. The methods of animal ethology, such as mice autonomous acti |
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| Keywords: | Gengnianan capsule Climacteric syndrome Sedative-hypnotic Learning and memory Anti-free radical Hyperlipemia |
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