Intermyofibrillar and nuclear-myofibrillar connections in human and canine myocardium. An ultrastructural study |
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Authors: | V J Ferrans W C Roberts |
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Institution: | Section of Pathology, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland, U.S.A. |
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Abstract: | Cytoplasmic filaments, which measure 100 Å in diameter, and which differ morphologically from actin and myosin filaments, are described in normal canine myocardium and in normal and hypertrophied human myocardium. These filaments were found between Z bands, near the sarcolemma, in regions of intercalated discs, and in the vicinity of nuclear membranes. The 100 Å filaments appeared to form transverse connections between adjacent Z bands and between Z bands and outer nuclear membranes. These filaments probably function as a cytoskeleton. |
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Keywords: | Address for reprint requests: Dr Victor J Ferrans Section of Pathology National Heart and Lung Institute National Institutes of Health Bethesda Maryland 20014 U S A |
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