| 兄妹肾阳虚证温补作用的系统生物学研究 |
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| 引用本文： | 潘玲,王建国,王米渠,许锦文.兄妹肾阳虚证温补作用的系统生物学研究[J].辽宁中医杂志,2009(2):193-196. |
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| 作者姓名： | 潘玲 王建国 王米渠 许锦文 |
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| 作者单位： | 成都中医药大学;新加坡国立大学防护技术中心;新加坡国立癌症研究中心; |
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| 基金项目： | 国家自然科学基金项目(90709053) |
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| 摘 要： | 目的:引入系统生物学的观察方法,研究温补药物治疗肾阳虚证兄妹疗效的分子生物学特征,探索基因芯片在中医诊治学中应用的可能性。方法:用40项肾阳虚证量表和40项寒证量表,调查一对兄妹在治疗前后的症状积分;用18816点阵的基因芯片测试在治疗前后的基因表达水平。结果:评定兄妹温补之后肾阳虚与寒证症状的积分下降1/3～2/3,得到在兄妹治疗前的差异表达治疗后入正常值的84条共同基因,其中38条已知基因功能,包括免疫、生长发育等6类。讨论:肾阳虚与寒证治疗效果可以用38条共同调节的基因表达水平和量表积分来分析,两者之间的相关关系值得深入探讨。从系统生物学的观点,用基因差异表达来评价辨证治疗疗效,为中医证的疗效评价提供了一个新的方法。
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| 关 键 词： | 肾阳虚证 系统生物学 疗效评价 温补中药 症状积分 基因芯片 |
System Biology Characteristics of Sibling Patients with Typical Kidney-yang Deficiency before and after Warming and Rrecuperating Drug Treatment |
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| PAN Ling,WANG Jian-guo,WANG Mi-qu,XU Jin-wen.System Biology Characteristics of Sibling Patients with Typical Kidney-yang Deficiency before and after Warming and Rrecuperating Drug Treatment[J].Liaoning Journal of Traditional Chinese Medicine,2009(2):193-196. |
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| Authors: | PAN Ling WANG Jian-guo WANG Mi-qu XU Jin-wen |
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| Institution: | 1.Chengdu University of Traditional Chinese Medicine;Chengdu;Sichuan Province 610075;China;2.Centre for Protective Technology;National University of Singapore;Singapore 119260;3.National Cancer Centre;Singapore 169610;China |
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| Abstract: | Objective:Identify the system biology characteristics before and after warming and recuperating drug treatments for sibling patients with typical Kidney-yang deficiency;explore the application of cDNA microarray in the assessment of therapeutic efficacy of Traditional Chinese Medicine.Methods:Use 40-items scoring tables for Kidney-yang deficiency syndrome and cold syndrome to obtain cumulative scores for pre-and post-warming and recuperating drug treatment of sibling patients with typical Kidney-yang defici... |
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| Keywords: | Kidney-yang deficiency syndrome System biology Treatment assessment Warming and recuperating drug Accumulated clinical scores cDNA microarry |
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