软肝健脾丸治疗慢性乙型肝炎肝纤维化的临床研究

目的：观察自制中药软肝健脾丸对慢性乙型肝炎肝纤维化的临床疗效。方法：将87例慢性乙型肝炎肝纤维化患者随机分为两组：治疗组44例,服用软肝健脾丸,对照组43例,服用安络化纤丸;治疗前后检测患者血清透明质酸（HA）、层粘蛋白（LN）、Ⅲ型前胶原（PCⅢ）、Ⅳ型胶原（Ⅳ-C）的水平,并观察主要症状、肝功能相关指标及肝脏B超声像图情况。结果：两组临床疗效比较,治疗组的显效率和总有效率分别为52.27%和88.63%;对照组分别为25.58%和67.44%,差异均有显著性意义（P〈0.01、P〈0.05）。HA、LN、PCⅢ、Ⅳ-C的水平治疗组患者治疗前后比较,差异有显著性意义（P〈0.01）;与对照组治疗后比较,差异均有显著性意义（P〈0.01、P〈0.05）。治疗组患者治疗前后ALT、AST、TBil、Alb比较差异有显著性意义（P〈0.01）,但与对照组治疗后比较差异无显著性意义（P〉0.05）。两组间在改善主要症状、脾脏回缩、肝脏声像图改变方面比较,差异有显著性意义（P〈0.05）。结论：软肝健脾丸对慢性乙型肝炎患者有较好的抗肝纤维化作用。

Clinical research on treatment of liver fibrosis in patients with chronic hepatitis B by Ruangan Jianpi pill

Objective：To research the clinical efficacy of Ruangan Jianpi pill on chronic hepatitis B liver fibrosis;Methods：Eighty-seven patients with chronic hepatitis B liver fibrosis were randomly divided into two groups： the treatment groups（n=44） were treated with Ruangan Jianpi pill,while the control group（n=43） were treated with Anluo Huaxian pill.before and after the treatment,the serum level of hyaluronic acid（HA）,type laninin（LN）,type Ⅲprocollagen peptide（PCⅢ）,type Ⅳ collagen（Ⅳ-C） were detected and the major clinical symptoms,liver function indicator,liver B ultrasound images were observed;Results：The markedly effective rate and the total effective rate in the treatment groups were 52.27% and 88.63%,and were 25.58% and 67.44% respectively in the control group,with differences striking（P0.01） and evident（P0.05） between the two group.There were striking differences in the serum level of HA,LN,PCⅢ,Ⅳ-C,ALT,AST,TBil,Alb between before and after treatment in the treatment group（P0.01）.After treatment,there were striking differences（P0.01） between two group in the serum level of HA,LN and significant differences（P0.05）.In the serum level of PCⅢ,Ⅳ-C,the major clinical symptoms improvement,shrinking splenomegaly,liver B ultrasound images change between the treatment group and the control group,but whereas there were no evident differences in the level of ALT,AST,TBil,Alb between the two group（P0.05）.Conclusion：Ruangan Jianpi pill can treat chronic hepatitis B liver fibrosis with better anti-hepatic fibrosis effect than Anluo Huaxian pill.