多囊卵巢综合征不同中医证型与内分泌代谢的相关性探索

目的 探讨多囊卵巢综合征（PCOS）的不同中医证型与内分泌代谢的相关性。方法 收集223例PCOS患者，其中脾虚组109例、肝虚组56例、肾虚组58例；同龄健康女性20名为对照组。测量体重指数（BMI）、腰臀比（WHR）；检测血清黄体生成素（LH）、卵泡刺激素（FSH）、雄激素（T）、泌乳素（PRL）、雌二醇（E2）、性激素结合球蛋白（SHBG）、空腹血糖（FBG）、空腹胰岛素（FINS）、血脂（TC、TG、LDL C、HDL C）、瘦素（leptin，Lp），比较各项指标的组间差异。结果 PCOS 3组的Lp、FINS、HOMA IRI、T、LH/FSH比值均显著高于对照组，SHBG均低于对照组（P<005,P<001）。Lp在PCOS 3组间比较差异无统计学意义；脾虚组FINS、HOMA IRI高于肾虚组及肝虚组（P<005, P<001）；肾虚组T、LH/FSH比值高于脾虚组及肝虚组（P<005）；肝虚组PRL高于脾虚组与肾虚组（P<001）。结论 血清Lp、SHBG异常为PCOS不同证型共同的病理表现；而不同证型有其各自的内分泌代谢变化的特点。

Study on the Correlation between Different Chinese Medicine Syndrome Types and Endocrine Metabolism of Polycystic Ovarian Syndrome

Objective To explore the correlation between different Chinese medicine syndrome types and endocrine metabolism of polycystic ovarian syndrome (PCOS).Methods 223 PCOS patients were recruited.Of tem,109 patients were classified as Pi deficiency type (PDT),56 as Gan deficiency type (GDT),and 58 as Shen deficiency type (SDT).And twenty healthy females of the same age ranges were enrolled as the control group.The body mass index (BMI) and waist hip ratio (WHR) were measured.Serum levels of luteinizing hormone (...