| 基于NOESY序列核磁共振技术冠心病心肌缺血血瘀证代谢组学的实验研究 |
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| 引用本文： | 赵慧辉,王勇,王英锋,王伟,李中峰,李春,郭淑贞,啜文静,陈建新. 基于NOESY序列核磁共振技术冠心病心肌缺血血瘀证代谢组学的实验研究[J]. 中国中西医结合杂志, 2011, 31(10): 1364-1368 |
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| 作者姓名： | 赵慧辉 王勇 王英锋 王伟 李中峰 李春 郭淑贞 啜文静 陈建新 |
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| 作者单位： | 1. 北京中医药大学药理教研室(北京100029)
2. 首都师范大学化学系(北京100037) |
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| 基金项目： | 国家科技重大专项基金，国家自然科学基金 |
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| 摘 要： | 目的 研究Ameriod环所致冠心病心肌缺血血瘀证小型猪的血清代谢物核磁共振谱群的变化。
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| 关 键 词： | 冠心病 ；血瘀证 ；核磁共振 ；代谢组学 |
Experimental Study on Metabonomics of Coronary Heart Disease Myocardial Ischemia of Blood Stasis Syndrome Based on the NOESY Pulse NMR |
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| WANG Yong,LI Zhong-feng and CHEN Jian-xin. Experimental Study on Metabonomics of Coronary Heart Disease Myocardial Ischemia of Blood Stasis Syndrome Based on the NOESY Pulse NMR[J]. Chinese journal of integrated traditional and Western medicine, 2011, 31(10): 1364-1368 |
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| Authors: | WANG Yong LI Zhong-feng CHEN Jian-xin |
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| Affiliation: | WANG Yong,LI Zhong-feng,CHEN Jian-xin,et alDepartment of Pharmacology,Beijing University of Chinese Medicine,Beijing(100029) |
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| Abstract: | Objective To study changes of serum metabolite profiles in Ameriod ring induced coronary heart disease(CHD) chronic myocardial ischemia(CMI) mini-pigs by NMR.Methods The blood stasis syndrome(BSS) animal model was established by coronary angiography,blood hemorheology,and so on.By using NMR and pattern recognition,changes of serum endogenous metabolites of the four-week mini-pigs of the BSS model and the sham-operative group.Results The model prepared by using this method was confirmed as the stable CHD CMI... |
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| Keywords: | coronary heart disease blood stasis syndrome nuclear magnetic resonance metabonomics |
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