壮族地区新生儿乙型肝炎疫苗免疫九年保护效果及免疫后HBsAg阳性者原因分析

乙肝免疫后９年，１１８３名１～９岁广西壮族儿童的保护性抗体阳性率为４３．８％，从免后１岁的８７．９％下降为３７．１％，但ＨＢｓＡｇ阳性率１．６％，未见随免疫年限延长而显著升高，疫苗保护率为８８．６％。免疫后儿童ＨＢｓＡｇ阳性８９．１％归因于母亲ＨＢｓＡｇ阳性。本研究结果表明乙肝疫苗免疫后９年不必加强免疫，只有采用高剂量免疫策略才能进一步降低ＨＢｓＡｇ阳性率。

Long-term Efficacy of Hepatitis B Vaccination in Infants in Zhuang Minority Area

1183 children aged 1-9 years immunized with hepatitis B vaccine 9 years later were randomly sampled to evaluate the efficacy of a low dose immunization started in 1987 in a Zhuang Minority Area.The crude anti-HBs positive rate was 43.8%,and the age-specific rates were ranged from 87.9% (lst year )to 37.1% (9th year).The crude HBsAg positive rate was 1.6% and the efficacy of vaccination against B was 86.6%.The results showed that there was no evidence of necessity for revaccination against hepatitis B at present,and the high-dose immunization straregy should be recommended for further declining HBsAg posi-tive rate in the area.