磁共振弥散张量成像观察创伤性胼胝体损伤

目的 探讨磁共振弥散张量成像对胼胝体损伤的潜在诊断价值.方法 应用磁共振弥散张量成像技术对25例闭合性颅脑损伤患者及20例健康志愿者进行观察,对胼胝体膝部、压部进行定量测定FA及ADC值,测定结果与患者组GCS进行相关分析.结果 患者组胼胝体膝部及压部的FA值较对照组显著下降(P＜0.05).患者组与对照组所测胼胝体ADC值差异无统计学意义(P＞0.05).患者组胼胝体FA值与GCS呈显著相关(P＜0.05).结论 磁共振弥散张量成像技术能清晰显示并定量与临床GCS评分密切相关的胼胝体损伤,为临床诊断及治疗提供有价值的更深层次的信息.

Magnetic resonance diffusion tensor imaging in traumatic corpus callosum injury

Objective To evaluate the potential clinical role for diffusion tensor imaging (DTI) in patients with traumatic corpus callosum injury. Methods Twenty-five closed traumatic brain injury patients (16 male,9 female; age 20-60,mean age 37) were evaluated by DTI with MR system. Quantitive analysis was performed using measurements of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in the genu and splenium of corpus callosum. The measurements were correlated with the clinical Glasgow Coma Scale (GCS),and the outcomes were compared with those of 20 healthy subjects (12 male,8 female; age 21-60,mean age 36). Results FA values of patient group significantly reduced within the genu and splenium of corpus callosum (P<0.05),compared with the control group. There was no significant difference of ADC measurements between control and patient group (P>0.05). FA values of corpus callosum (P<0.05) were significantly correlated with the GCS. Conclusion DTI reveals the diffuse axonal injury change of corpus callosum correlated with the clinical GCS,being able to provide valuable further information to traumatic brain injury cases.