Cyclin D1在胃癌中的表达

目的：探讨CyclinD1蛋白表达与胃癌发生发展及其与组织类型的关系。方法：有用S－P免疫组化技术，检测胃癌组织中CyclinD1蛋白的表达。结果：在63例胃癌标本中有20例CyclinD1阳性表达，阳性率为31．75％。50岁以下年龄组胃部CyclinD1阳性表达明显高于50岁以上年龄组（P＜0．05）。CyclinD1在胃癌不同组织类型中的表达无显著性差异（P＞0．05）。在癌周和萎缩性类，非典型增生的胃粘膜也可见CyclinD1阳性表达。结论：CyclinD1蛋白过度表达与胃癌发生发展有关，与胃癌的组织类型没有明显关系。

Expression of Cyclin D1 in Gastric Carcinoma

Objective: Cyclin D1 is encoded by PRAD1 and CCND1 genes, and is possibly a oncogene protein. This paper is to investigate the correlation of cyclin D1 expression with pathogenesis and development and with histological type of gastric carcinoma. Methods: The expression of cyclin D1 in gastric carcinoma was observed by means of immunohistochemical method. Results: Out of 63 cases of gastric carcinoma, 20(31.75%) showed immunostaining positive. The positive staining in patient, aged<50 years, was significantly higher than that of patients aged over 50 year (P<0.05).Cyclin D1 positive immunostaining in mucosa of peri-cancer, atypical hyperplasia and atrophic gastritis was occasionally seen. There was no significant difference of cyclin D1 expression among the different histological types and invasive depths of gastric carcinoma. Conclusion: The expression of cyclin D1 is related with the development of gastric carcinoma and independent of the histological types of gastric carcinoma.