老年慢阻肺急性加重期应用C反应蛋白与降钙素原作为预后评价标志物的意义

目的探讨老年慢性阻塞性肺疾病（慢阻肺）急性加重期应用C反应蛋白与降钙素原作为预后评价标志物的意义。方法选取100例老年慢阻肺急性加重期患者和100例稳定期患者,测定患者血清中C反应蛋白（CRP）与降钙素原（PCT）的含量,并通过对应的FEV1/FVC值与FEV1%值分析患者肺功能和对应的死亡率变化。结果急性加重期组和感染组患者CRP浓度（分别为57.6±12.2和77.6±15.9 mg/L）与PCT浓度（分别为1.06±0.32和1.57±0.36μg/L）明显高于稳定期组和非感染组CRP（24.5±6.2和30.4±6.6 mg/L）和PCT（0.15±0.06和0.25±0.08μg/L）,相比较差异具有统计学意义（P〈0.001）;急性加重期组和感染组患者死亡率也显著高于稳定期组和非感染组,肺功能明显差于稳定期组和非感染组。结论 C反应蛋白与降钙素原随着老年慢性肺阻塞肺疾病病情（肺功能和患者死亡率）的变化而发生变化,是一种老年慢性肺阻塞性肺疾病良好的预后评价标志物。

Significance of applying C reactive protein and procalcitonin as the evaluation of prognostic marker in acute exacerbation of aged chronic obstructive pulmonary disease

Objective To investigate significance of applying C reactive protein and procalcitonin as the evaluation of prognosis marker in acute exacerbation of aged chronic obstructive pulmonary disease（COPD）. Methods 100 cases of acute exacerbation of aged COPD patients and 100 stable patients, determination of the contents of CRP and PCT in serum of patients, and through the corresponding FEV1/FVC value changes of lung function and mortality of patients with FEVI% values. Results Concentration of CRP and PCT in acute exacerbation group（57.6 ± 12.2）rag/L, （1.06 ± 0.32）μg/L] and infection group（77.6 ± 15.9） rag/L, （1.57 ± 0.36） μg/L] significantly higher than that in stable stage group（24.5 ± 6.2）μg/L, （0.15 ± 0.06） μg/L] and non infection group（30.4±6.6） mg/L, （0.25 ± 0.08）μg/L], compared with a very significant difference, P〈0.001; mortality rate of acute exacerbation group and infection group was significantly higher than those in stable stage mortality group and non infection group, the lung function was worse in the stable group and non infection group. Conclusion C reactive protein and procalcitonin vary with aged chronic pulmonary obstructive pulmonary disease （pulmonary function and mortality） change, which make it a good evaluation of prognostic marker for aged chronic obstructive pulmonary disease.