专项干预对老年冠心病合并牙周炎患者口腔、外周血及龈沟液炎性指标影响

目的：观察专项干预对老年冠心病（CHD）合并牙周炎患者口腔、外周血及龈沟液（GCF）炎性指标影响。方法连续选择近期在解放军沈阳军区总医院心内科住院治疗的老年CHD合并牙周炎患者45例。入选对象随机分为口腔干预组（23例）和对照组（22例）。两组患者均接受了常规冠心病治疗，口腔干预组另接受了口腔专项干预治疗。治疗前后进行了口腔、外周血及GCF处炎性指标检测。结果两组患者治疗前各类口腔及牙周相关指标接近，治疗后口腔干预组的PD、CAL、M、SBI及OHI-S均明显好于治疗前及对照组同期结果（P均〈0.05）；两组患者治疗前外周血炎性标识指标水平接近，两组患者治疗后外周血炎性标识指标水平均明显低于治疗前，同时，口腔干预组的IL-1β、IL-6、TNF-α和hs-CRP表达水平均显著低于对照组（P均〈0.05）；两组患者治疗前GCF处炎性标识指标水平接近，治疗后口腔干预组GCF处IL-1β、IL-6和TNF-α水平均显著低于治疗前及对照组同期结果（P均〈0.05~0.01）。结论专项干预可明确改善老年冠心病（CHD）合并牙周炎患者口腔、外周血及龈沟液（GCF）炎性指标。

Effect of special intervention on expression of inflammatory factors in peripheral blood and gingival crevicular fluid of elderly patients with coronary heart disease and periodontitis

Objective To investigate the effect of special intervention on the expression of inflammatory factors in the oral cavity, peripheral blood and gingival crevicular fluid （GCF） of elderly patients with coronary heart disease （CHD） and periodontitis. Methods A total of 45 elderly patients with CHD and periodontitis were selected from Department of Cardiology, General Hospital of Shenyang Military Area Command of Chinese PLA and divided into intervention group （n=23） and control group （n=22）. All the cases were treated by general therapy;meanwhile, the cases in the intervention group were also treated by special intervention. Inflammatory factors in the oral cavity, peripheral blood and GCF were tested before and after treatment. Results Related indicators of oral cavity and periodontium were similar between the two groups before the treatment. However, expressions of PD, CAL, M, SBI and OHI-S in the intervention group after the treatment were significantly higher than those before the treatment and those in the control group （P〈0.05~0.01）. Expressions of inflammatory factors in the peripheral blood were similar between the two groups before the treatment. After the treatment, the expressions of inflammatory factors in the intervention group were significantly lower than those before the treatment;meanwhile, the expressions of IL-1β, IL-6, TNF-αand hs-CRP in the intervention group were significantly lower than those in the control group （P〈0.05~0.01）;in the GCF, expressions of inflammatory factors were similar between the two groups before the treatment, but the expressions of IL-1β, IL-6 and TNF-αin the intervention group after the treatment were significantly lower than those before the treatment and those in the control group （P〈0.05~0.01）. Conclusion A special intervention can significantly improve expressions of inflammatory factors in the oral cavity, peripheral blood and GCF of elderly patients with CHD and periodontitis.