急性心肌梗死静脉溶栓治疗开始时间与疗效的关系

目的 观察急性心梗后不同时间溶栓与疗效的关系。方法 对１９０例患者分为两组，治疗组用国产尿液酶２５Ｕ／ｋｇ；对照组用极化液１００ｍｌ静滴。记录用药前，用药后即刻及３ｈ，８ｈ，１２ｈ心电图抬高的Ｓ－Ｔ段平方面积（ｍｍ＾２）。结果 用药后３ｈＳ－Ｔ段下降水平明显，〉５０％，８ｈ内溶栓效果继续发挥作用。结论 入院６ｈ内用药病死率低（９．４％），给药时间延迟病死率明显递增。

The relationship between the starting time of thrombolytic treatment and efficacy in acute myocardial infarction.

Objective To assess the relationship between the starting time of urokinase treatment and its efficacy in AMI patients. Methods 106 patients (group A) were treated with intravenous infusion of urokinase, and 84 patients (group B) without urokinase. The coronary revascularization rate, ischemic area and in-hospital mortality in the two groups and at various starting time of thrombolytic treatment within group A were determined. Results The ischemic area and in-hospital mortality of group A were lower than that of group B. In group A, the coronary revascularization rate of subgroup with treatment starting time at 6-hour, 12-hour and 24-hour from the onset of AMI was 64%, 47% and 26% respectively. The mortality increased significantly as treatment delayed. Conclusion The efficacy of thrombolytic treatment starting within 6 hours from onset of AMI is the best, but it is still effective at 24-hour.