颈康宁胶囊对小鼠脑缺血的影响

目的观察颈康宁胶囊对小鼠脑缺血的影响。方法以生理盐水组为阴性对照,尼莫地平组为阳性对照,小鼠分别灌胃给予不同剂量颈康宁胶囊(0.75,1.5和3.0 g.kg-1),观察颈康宁胶囊对断头小鼠喘气时间的影响、对结扎双侧颈总动脉及迷走神经小鼠存活时间的影响。结果颈康宁胶囊(3.0 g.kg-1)能明显延长断头小鼠喘气时间、结扎双侧颈总动脉及迷走神经小鼠存活时间(P<0.01),颈康宁胶囊(1.5 g.kg-1)能明显延长断头小鼠喘气时间(P<0.05)。结论颈康宁胶囊对小鼠脑缺血有保护作用。

Influence of Jingkangning Capsules on cerebral ischemia in mice

Objective To observe the influence of different dose Jingkangning Capsules on cerebral ischemia in mice.Methods The group with 0.9% sodium chloride were used as the negative,the group with nimodipine were used as the possive,and the influence of different dose Jingkangning capsules by intragastric feeding((0.75,1.5,3.0 g·kg~(-1)))on the duration time of the mice without head and the mice with both common carotid artery and vagus ligature was studied.Results Jingkangning Capsules(3.0 g·kg~(-1))fairly increased the duration time of the mice without head and the mice with both common carotid artery and vagus ligature((P<0.01)).Jingkangning Capsules(1.5 g·kg~(-1))increased the duration time of the mice without head((P<0.05)).Conclusion Jingkangning Capsules possess the effect against cerebral ischemia in mice.