Autoradiographic localization of prazosin and rauwolscine binding sites in the human kidney |
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Authors: | P Neumann H -J Gröne E Fuchs |
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Institution: | 1. Deutsches Primatenzentrum, G?ttingen, FRG 2. Institute of Pathology, University of G?ttingen, FRG
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Abstract: | In the human kidney, binding sites for the alpha1-adrenoceptor antagonist3H-prazosin and the alpha2-adrenoceptor antagonist3H-rauwolscine were localized and quantified byin vitro autoradiography.3H-prazosin binding was found predominantly in the renal cortex. In the medulla, tubular structures were also specifically
labelled. No binding sites, however, were detected in association with glomeruli or large blood vessels.3H-rauwolscine labelled the medullary vascular bundles intensively, but no binding sites were associated with glomeruli or
other cortical structures. Thus, the binding pattern for3H-prazosin is quite similar in both human and rat renal cortex. There are, however, distinct differences between human and
rat kidneys in the distribution of the alpha2-adrenergic binding sites visualized with the antagonist3H-rauwolscine. |
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