肺癌基因异常表达与化疗药物的相关性分析

Correlation of Aberrantly Expressed Lung Cancer Genes and Chemotherapy Drugs

Objective To explore the relationship between aberrantly expressed genes in lung cancer genesand after chemotherapy by gene expression profi le. Methods In this article, expression profi le of lung cancertissue and normal lung tissue were compared to screen out the differentially expressed genes by statisticalmethod. The aberrant expressed genes of lung cancer cells were clarifi ed. Then the up-regulated aberrantlyexpressed genes were upregulated by the chemotherapy drugs were selected by association analysis. Finally,the genes which could correspond to many chemotherapy drugs were screened and analyzed by networkregulation, to clarify the possible regulation relationship between these genes. Results Three hundred andninety-seven up-regulated aberrantly expressed genes induced by 6 kinds of related chemotherapy drugs inlung cancer tissue were screened out. Among them, TOP2A，MAD2L1，BIRC5 corresponded to manychemotherapy drugs and MAD2L1 may control the biological function of TOP2A and BIRC5 through P53.Conclusion The up-regulated expression genes, TOP2A，MAD2L1 and BIRC5, may have correlation withthe effect of chemotherapy of lung cancer. MAD2L1 may infl uence the biological function of TOP2A andBIRC5.