| 神经菌毛素促进VEGF介导的血管生成作用及其机制研究进展 |
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| 引用本文： | 徐之超,陈晨,李文智,陈强,姚春和,耿西林,王林,耿智敏.神经菌毛素促进VEGF介导的血管生成作用及其机制研究进展[J].肿瘤防治研究,2014,41(4):409-412. |
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| 作者姓名： | 徐之超 陈晨 李文智 陈强 姚春和 耿西林 王林 耿智敏 |
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| 作者单位： | 710061 西安，西安交通大学第一附属医院肝胆外科 |
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| 基金项目： | 国家自然科学基金资助项目（30971340） |
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| 摘 要： |
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| 关 键 词： | 神经菌毛素 血管内皮生长因子 血管形成 |
| 收稿时间： | 2013-01-16 |
Research Progression on Angiogenesis Effect and Mechanism of VEGF Promoted by NRP-1 |
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| XU Zhichao,CHEN Chen,LI Wenzhi,CHEN Qiang,YAO Chunhe,GENG Xilin,WANG Lin,GENG Zhimin.Research Progression on Angiogenesis Effect and Mechanism of VEGF Promoted by NRP-1[J].Cancer Research on Prevention and Treatment,2014,41(4):409-412. |
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| Authors: | XU Zhichao CHEN Chen LI Wenzhi CHEN Qiang YAO Chunhe GENG Xilin WANG Lin GENG Zhimin |
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| Institution: | Department of Hepatobiliary, The First Affiliated Hospital of Xi'an JiaoTong University,
Xi'an 710061,China |
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| Abstract: | Neuropilin-1(NRP-1), acted as one important member of NRP family,expressed in endothelial cellsand certain tumour cells and conducted common receptor of Sema 3A,VEGF,PDGF and TGF. Therefore, itplays an important role in axon growth,angiogenesis and tumor growth. VEGF acts as one important regulatingfactor in angiogenesis, also played an important role in tumor angiogenesis, growth and development. Moreand more researches had confi rmed that VEGF could facilitate angiogenesis, tumor growth and developmentas combined with NRP-1. This article mainly summarizes angiogenesis and mechanism of VEGF promotedby NRP-1. |
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| Keywords: | Neuropilin-1(NRP-1) VEGF Angiogenesis |
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