| 结直肠癌中miRNA基因及其靶基因多态性位点的研究进展 |
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| 引用本文： | 朱陵君,陈志鹏,王美林,陈 涛,束永前. 结直肠癌中miRNA基因及其靶基因多态性位点的研究进展[J]. 肿瘤防治研究, 2014, 41(1): 69-73. DOI: 10.3971/j.issn.1000-8578.2014.01.016 |
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| 作者姓名： | 朱陵君 陈志鹏 王美林 陈 涛 束永前 |
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| 作者单位： | 1. 210029 南京，南京医科大学第一附属医院肿瘤科;2.南京医科大学公共卫生学院分子毒理学实验室；3. 南京医科大学第一附属医院普外科 |
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| 基金项目： | Colorectal cancer; miRNA; Target gene; Polymorphism |
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| 摘 要： | 结直肠癌是最常见的消化系统肿瘤之一。近年来的研究表明，miRNA在结直肠癌的发病过程起着重要的作用。由于单核苷酸多态性（SNPs）的存在，miRNA的结构和功能可能发生变化，从而影响结直肠癌的发病率。目前国内外对miRNA及其靶基因多态性与结直肠癌的关系研究不多。在本文中，我们将对结直肠癌中miRNA表达谱的改变、miRNA基因及其靶基因多态性与结直肠癌的关系及miRNA基因多态性对于结直肠癌的诊断、预后判断、预测疗效的应用前景等内容进行综述。
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| 关 键 词： | 结直肠癌 miRNA 靶基因 态性 |
| 收稿时间： | 2012-10-02 |
Study Advancement of MicroRNA and Its Target Gene Polymorphism and Colorectal#br# Tumorigenesis |
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| ZHU Lingjun,CHEN Zhipeng,WANG Meilin,CHEN Tao,SHU Yongqian. Study Advancement of MicroRNA and Its Target Gene Polymorphism and Colorectal#br# Tumorigenesis[J]. Cancer Research on Prevention and Treatment, 2014, 41(1): 69-73. DOI: 10.3971/j.issn.1000-8578.2014.01.016 |
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| Authors: | ZHU Lingjun CHEN Zhipeng WANG Meilin CHEN Tao SHU Yongqian |
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| Affiliation: | 1.Department of Oncology, The First Afflilated Hospital of Nanjing MedicalUniversity,Nanjing 210029,China; 2. Department of Molecular and Genetic Toxicology,The Key Laboratory of Modern Toxicology of Ministry of Education,School of PublicHealth,Nanjing Medical University; 3.Department of General Surgery, The First AffiliatedHospital of Nanjing Medical University |
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| Abstract: | Colorectal cancer(CRC) is one of the most common cancers worldwide. Recent years, some studiesshow that miRNAs contribute to the development of CRC. Single Nucleotide Polymorphisms (SNP) ofmiRNAs alos may be the risk of CRC due to change their structure and function.. In this review, alterations ofmiRNAs in CRC and the relation between SNPs in miRNAs and target sites and CRC risk would be showed.Furthermore, the SNPs in miRNAs may be useful in diagnose and prognosis of CRC and so on. |
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| Keywords: | Colorectal cancer miRNA Target gene Polymorphism |
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