上皮间叶转化相关蛋白在三阴性乳腺癌组织中的联合表达及其与预后的关系

目的 检测上皮间叶转化相关蛋白E-cadherin、β-catenin和Vimentin在三阴性乳腺癌中的联合表达及其与预后的关系。方法 免疫组织化学分别检测E-cadherin、β-catenin和Vimentin在51例三阴性乳腺癌中的表达，分析其联合表达与预后的相关性。结果 E-cadherin或β-catenin表达的缺失或Vimentin表达的增高均为异常表达。3项均正常、1~2项不正常以及3项均不正常的病例数分别为1例(1.96%)、37例(72.55%)、13例(25.49%)。3项均不正常组的5年内无瘤生存较其他组明显缩短（Logrank检验，P<0.01）。结论 上皮间叶转化相关蛋白E-cadherin、β-catenin和Vimentin的联合检测有助于区分三阴性乳腺癌的异质性。

Combined Expressions of Epithelial-Mesenchymal Transition Related Proteins in Triple-#br# Negative Breast Cancer and Its Prognostic Signifi cance

Objective To investigate the relationship between expressions of epithelial-mesenchymaltransition related proteins(E-cadherin, β-catenin and Vimentin) and prognosis in triple-negative breastcancer. Methods The expressions of E-cadherin, β-catenin as well as Vimentin were examined byimmunohistochemistry in 51 patients with breast cancer. The relation between combined expression of 3markers and prognostic signifi cance was analyzed. Results The loss of E-cadherin or β-catenin expressionand over-expression of Vimentin were defined as abnormal expression. The cases with 3 markers normalexpressions, 1-2 markers normal expressions, and 3 markers abnormal expressions were 1(1.96%), 37 (72.55%)and 13 (25.49%), respectively.Patients with abnormal expression of 3 markers had shorter disease freesurvival (DFS) ,compared with those without. Conclusion The combined expression of E-cadherin,β-cateninas well as Vimentin were useful in discriminating the heterogeneity of triple-negative breast cancer.