广州市黄埔区416例生殖道感染妇女支原体感染状况及药敏分析

目的研究解脲脲原体、人型支原体在广州黄埔区生殖道感染妇女中的感染状况及支原体感染的耐药情况。方法采用解脲脲原体和人型支原体培养鉴定药敏试剂盒检测416例生殖道感染妇女支原体感染情况与及其药敏试验结果。结果416例受试妇女中支原体检出率为48．6％，以解脲脲原体为主（35．6％），阴道炎患者总感染率（56．7％）高于宫颈炎患者（39．1％）（P〈0．01）。支原体对交沙霉素（93．6％）、强力霉素（87．1％）、美满霉素（87．1％）较为敏感，对罗红霉素耐药率最高（47．5％）。Uu耐药率最高的是司帕沙星（43．1％），Mh耐药率最高的是克拉霉素、罗红霉素和阿奇霉素（均为100％）；Uu和Mh混合感染对常用抗生素普遍耐药。结论本地区生殖道感染妇女患者的支原体感染主要为解脲脲原体，支原体的不同感染类型耐药性不一致，临床应参照药敏试验结果选用抗菌药物。交沙霉素、美满霉素和强力霉素是经验治疗首选用药。

THE DETECTION OF MYCOPLASMA INFECTION AND DRUG RESISTANCE STATUS IN 416 WOMEN WITH GENITAL TRACT INFECTION IN HUANGPU DISTRICT OF GUANGZHOU

Objective To study the ureaplasmaurealyticum（Uu） and mycoplasma hominis, （Mh） infection and drug resistance status in women with genital tract infection in Huangpu District of Guangzhou. Methods The Mycoplasma ICS Kit was used to test mycoplasma infection and drug susceptibility status in 416 genital infection women. Results In 416 eases of genital tract infection women, the positive rate of mycoplasma were 48. 6%, main infectious mycoplasma was the Uu（35.6% ）. Among these cases, the mycoplasma infection rate in Colpitis cases （56. 7 % ） higher than cases with cervicitis （39. 1% ） （p 〈 0. 01 ）. In the drug resistance and sensitive test, the myco- plasma was most sensitive to JOS（93.6% ） ,MIN（87.1% ）, DOX（87. 1% ） ,and most resistant to ROX（47. 5% ）. Uu was most resistant to SPA（47. 5% ）, Mh was most resistant to CLA ROX and AZI（ 100% ） ,Uu and Mh mixed in-fection was generally resistant to commonly used antibiotics. Conclusion In the genital tract infection women of this area, Uu was the most common mycoplasma infection, mycoplasma infection types resulted in the drug resistance and sensitivity, the antibiotics should be chose with drug sensitive test. JOS, MIN and DOX were the first choice for expe-riential therapy.