早期干预对预防脑卒中后应激性溃疡出血的作用

目的探讨早期应用抑酸荆对急性脑卒中后应激性溃疡出血的预防作用。方法急性脑卒中病人184例随机分成两组，治疗组（奥美拉唑）和对照组（无药物预防）。测定不同时间胃液pH值，观察两组病人应激性溃疡出血的发生率、病死率。结果入院时两组病人pH值均无差异．应用奥美拉唑后治疗组DH值显著升高，治疗组溃疡出血发生率为8．5％，病死率为3．8％．明显低于对照组的25．6％和11．5％（P〈0．05）。结论早期干预可以降低急性脑卒中后应激性溃疡出血的发生率和病死率。

The Effect of Primary Intervention for Stress Ulceration Bleeding in Patients with Acute Stroke

Objective To study the prevention of stress ulceration bleeding in patients (pts) with acute stroke.Methods One hundred and eighty-four pts with acute stroke were divided randomly into 2 groups,and treated by Omeprazole or by regular drugs. The pH of gastric juice was determined.The incidence and mortality of stress ulceration bleeding was observed.Results On admission,the pH was not significantly different between two groups. The pH was significantly increased in treatment group following Omeprazole. The incidence and mortality of stress ulceration bleeding in treatment group were lower than that in the control.Conclusion The primary intervention by Omeprazole in pts with acute stroke could reduce the incidence and mortality of stress ulceration bleeding.