| MDMA的神经毒性及SERT mRNA的表达 |
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| 引用本文： | 王雪,彭祖贵,况伟宏,康林,黄明生,李静. MDMA的神经毒性及SERT mRNA的表达[J]. 中国药物依赖性杂志, 2004, 13(4): 272-274 |
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| 作者姓名： | 王雪 彭祖贵 况伟宏 康林 黄明生 李静 |
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| 作者单位： | 四川大学华西医院精神科,成都,610041 |
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| 摘 要： | 目的 :探讨MDMA的神经毒性及SERTmRNA的表达。方法 :设立对照组和实验组 ,实验组给予MDMA(2 0mg·kg- 1 ,每日 2次 ,ip ,连续 4d) ,对照组给予等体积生理盐水。采用高效液相色谱法测定不同脑区的DA和 5 -HT含量 ,原位杂交方法检测SERTmRNA的表达。结果 :给予MDMA后 ,大鼠额叶皮层、海马和纹状体的 5 -HT下降 (P <0 0 0 1) ,SERTmRNA的表达明显减少 (P <0 0 0 1)。结论 :MDMA对中枢 5 -HT系统有明显的神经毒性 ,导致SERTmRNA表达下调。
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| 关 键 词： | 3,4亚甲基二氧基甲基苯丙胺 神经毒性 5-羟色胶转运体 核糖核酸信使 |
| 修稿时间： | 2003-06-02 |
THE NEUROTOXICITY AND SERT mRNA EXPRESSION OF MDMA |
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| WANG Xue,PENG Zugui,KUANG Weihong,KANG Lin,HUANG Mingsheng,LI Jing. THE NEUROTOXICITY AND SERT mRNA EXPRESSION OF MDMA[J]. Chinese Journal of Drug Dependence, 2004, 13(4): 272-274 |
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| Authors: | WANG Xue PENG Zugui KUANG Weihong KANG Lin HUANG Mingsheng LI Jing |
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| Abstract: | Objective: To explore the neurotoxicity and SERT mRNA expression of MDMA.Methods: Control group(A) and experimental group(B) were established; rats in Group A were administered with saline, in Group B with MDMA(ip);DA and 5-HT were measured by HPLC, and the expression of SERT mRNA was detected by in situ hybridization. Results: MDMA caused the decrease of 5-HT in rat frontal cortex, hippocampus and striatum,but no significant influence on DA; the expression of SERT mRNA was down-regulated significantly. Conclusion: MDMA can cause neurotoxicity to 5-HT system of central nervous system, and down-regulate the expression of SERT mRNA. |
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| Keywords: | MDMA neurotoxicity SERT mRNA |
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