焦虑抑郁对心脏起搏患者细胞黏附分子和纤溶活性的影响

目的观察焦虑抑郁心理状况对心脏起搏患者细胞粘附分子、纤溶活性的影响.方法选择39例经过症状自评量表(SCL-90)评定有焦虑抑郁心理问题的心脏起搏患者为研究组及32例无心理问题的心脏起搏患者为观察对照组,另选择25例健康体检者为对照组,分别测其血浆细胞粘附分子血浆可溶性P选择素(P-Selectin)、E-选择素(E-Selectin)、可溶性细胞间粘附分子-1(sICAM-1)、血管性假性血友病因子(vWF)及血浆纤溶酶原激活剂抑制物-1(PAI-1)水平.结果心脏起搏患者血浆细胞粘附分子水平明显高于健康对照组(P＜0.01),其中有焦虑抑郁心理问题者又明显高于无焦虑抑郁者(P＜0.05).结论心脏起搏患者存在高水平的细胞黏附分子的表达,纤溶活性明显下降,而焦虑抑郁状况则进一步加重了这种影响.

The Effect of Anxiety and Depression on Cell Adhesion Molecules and Fibrolytic Activity in Cardiac-pacing Patients

Objective To observe the effect of anxiety and depression on cell adhesion molecules and fibrolytic activity in cardiac-pacing patients. Methods The levels of plasma P-selectin, E-selectin, sICAM-1, vWF and PAI-1 were measured in 39 cardiac-pacing patients with anxiety or depression as rersearch group, 32 cases cardiac-pacing patients without any psychological problems as observation control group and 20 healthy subjects as normal control group. Result The levels of plasma P-selectin, E-selectin, sICAM-1, vWF and PAI-1 in cardiac-pacing patients were significantly higher than those in normal control group, and their plasma levels in the patients with anxiety or depression were significantly higher than those in the patients without psychological problems. Conclusion There were significantly elevated cell adhesion molecules level and decreased fibrolytic activity in cardiac-pacing patients. The anxety and depression status could aggregate this condition.