|
|||||
|
|
Cognitive decline is associated with nutritional risk in subjects with small head circumference (HC) |
|
| Authors: | Kang Soo Lee Hae-Kwan Cheong Hae Sun Jung Chang Hyung Hong |
| Institution: | a Department of Psychiatry, CHA University Bundang cha hospital, Yatap-dong 351, Bundang-gu, Seongnam-Si, Kyounggi-Do 463-712, South Korea b Department of Medicine, the Graduate School, Yonsei University, Sungsan-ro 262, Shinchon-dong, Seodaemun-gu, Seoul 120-752, South Korea c Department of Social and Preventive Medicine, Sungkyunkwan University School of Medicine, Cheoncheon-dong 330, Jangan-gu, Suwon-si, Gyeonggi-do 440-746, South Korea d Department of Psychology, Chungbuk National University, Seongbong-ro 410, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do 361-763 South Korea e Gwangju Mental Health Center, Gosan-ri 253-3, Opo-eup, Gwangju-si, Gyeonggi-do 443-749, South Korea f Department of Psychiatry, Ajou University School of Medicine, San 5, Woncheon-dong Yeongtong-gu, Suwon-si, Gyeonggi-do 443-749, South Korea g Ajou Institute of Aging, Ajou University School of Medicine, San 5, Woncheon-dong Yeongtong-gu, Suwon-si, Gyeonggi-do 443-749, South Korea h Memory Impairment Center, Ajou University Hospital, San 5, Woncheon-dong Yeongtong-gu, Suwon-si, Gyeonggi-do 443-749, South Korea |
| Abstract: | Nutrition has been found to be associated with cognitive impairment, but it has not been established whether these associations are present solely in later life or whether they are present in younger age as well. HC is a good indicator of brain development and the most sensitive anthropometric indicator of prolonged malnutrition during early life. This study examined the interaction between early HC and later (nutrition screening initiative) nutritional factors on the risk of cognitive decline in the elderly. The longitudinal factorial design had the mini-mental state examination (MMSE) score as the dependent variable, with HC as one factor and nutritional risk as another. We studied a sample of 495 not cognitively impaired Korean participants with 2 years follow-up data. After multivariable adjustment, interactive effect between HC and nutritional risk was significantly associated with cognitive decline (F = 2.449, p = 0.045). Simple main effect analysis showed that compared with highest HC, lowest HC was associated with a cognitive decline. Nutritional risk was associated with cognitive function decline only in individuals with small HC. Therefore, the prevention for cognitive impairment and dementia should involve nutritional strategies throughout life. |
| Keywords: | Head circumference Nutritional risk Nutrition screening initiative Cognitive decline Mini-mental state examination (MMSE) |
| 本文献已被 ScienceDirect 等数据库收录！ | |