| Polylactic Acid Nanoparticles Targeted to Brain Microvascular Endothelial Cells |
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| 引用本文： | 王华芳 胡豫 孙望强 谢长生. Polylactic Acid Nanoparticles Targeted to Brain Microvascular Endothelial Cells[J]. 华中科技大学学报(医学英德文版), 2005, 25(6): 642-644. DOI: 10.1007/BF02896158 |
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| 作者姓名： | 王华芳 胡豫 孙望强 谢长生 |
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| 作者单位： | [1]Institute of Hematology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China [2]Nano Pharmaceutical Research Center, Huazhong University of Science ＆ Technology, Wuhan 430074 , China |
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| 基金项目： | This work was supported by the National Natural Science Foundation of China （ No. 30170392 and 50271029）. |
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| 摘 要： | In this work, blank polylactic acid （PLA） nanoparticles with unstained surface were prepared by the nano-deposition method. On the basis of the preparation, the effect of surface modification on brain microvascular endothelial cells （BMECs） targeting was examined by in vivo experiments and fluorescence microscopy. The results showed that PLA nanoparticles are less toxic than PACA nanoparticles but their BMECs targeting is similar to PACA nanoparticles. The experiments suggest that drugs can he loaded onto the particles and become more stable through adsorption on the surface of PLA nanoparticles with high surface activity. The surface of PLA nanoparticles was obviously modified and the hydrophilicity was increased as well in the presence of non-ionic surfactants on PLA nanoparticles. As a targeting moiety, polysobate 80 （T-80） can facilitate BMECs targeting of PLA nanoparticles.
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| 关 键 词： | 乳酸 微脉管 内皮细胞 大脑血管 |
| 收稿时间： | 2005-09-25 |
Polylactic acid nanoparticles targeted to brain microvascular endothelial cells |
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| Wang Huafang,Hu Yu,Sun Wangqiang,Xie Changsheng. Polylactic acid nanoparticles targeted to brain microvascular endothelial cells[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2005, 25(6): 642-644. DOI: 10.1007/BF02896158 |
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| Authors: | Wang Huafang Hu Yu Sun Wangqiang Xie Changsheng |
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| Affiliation: | 1. Institute of Hematology, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022, China
2. Nano Pharmaceutical Research Center, Huazhong University of Science & Technology, Wuhan 430074, China |
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| Abstract: | In this work, blank polylactic acid (PLA) nanoparticles with unstained surface were prepared by the nano-deposition method. On the basis of the preparation, the effect of surface modification on brain microvascular endothelial cells (BMECs) targeting was examined by in vivo experiments and fluorescence microscopy. The results showed that PLA nanoparticles are less toxic than PACA nanoparticles but their BMECs targeting is similar to PACA nanoparticles. The experiments suggest that drugs can be loaded onto the particles and become more stable through adsorption on the surface of PLA nanoparticles with high surface activity. The surface of PLA nanoparticles was obviously modified and the hydrophilicity was increased as well in the presence of non-ionic surfactants on PLA nanoparticles. As a targeting moiety, polysobate 80 (T-80) can facilitate BMECs targeting of PLA nanoparticles. |
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| Keywords: | polylactic acid nanoparticles, polysorbate brain microvascular endothelial cells targeting |
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