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Prevalence of suspected periodontal pathogens identified using ELISA in adolescents of differing ethnic origins
Authors:R. Ellwood  H.V. Worthington  M.P. Cullinan  S. Hamlet  V. Clerehugh  R. Davie
Affiliation:Dental Health Unit, Manchester, UK.;University of Queensland, Australia;Leeds Dental Institute, Leeds, UK
Abstract:Abstract The aim of this study was to determine the prevalence of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis and Prevotella intermedia in a group of adolescents and investigate the association of these organisms with various clinical parameters. A total of 527, 11-13-year-old children, of whom 333 (63%) were white Caucasian, 187 (35%) Indo-Pakistani and 7 (1%) Afro-Caribbean, participated in the study. Subgingival plaque samples, collected from the mesio-buccal of both upper first permanent molars using sterile paper points, were stored in phosphate buffered saline with 0.01% thiomersal and analysed for the presence of A. actinomycetemcomitans, P. gingivalis and P. intermedia using ELISA. The mesio-buccal sites of both upper 1st permanent molars were also examined and the presence/absence of supragingival plaque, subgingival calculus, bleeding on probing and pocket depths greater than 3 mm were recorded. The % of white Caucasian children in whom the monoclonal antibody identified at least 1 site with A. actinomycetemcomitans, P. gingivalis and P. intermedia were 4%, 3% and 2%, respectively, and for Indo-Pakistanis were 3%, 17% and 2%. The difference for P. gingivalis was statistically significant (p < 0.001). The associations between the clinical parameters and the 3 organisms were considered separately for both upper first molar sites. The prevalence of P. gingivalis was higher for sites with subgingival calculus, pockets >3 mm and bleeding on probing (p < 0.001).
Keywords:adolescents    periodontal disease    calculus    ethnicity    A. actinomycetemcomitans: P. gingivalis P. intermedia
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