| 糖皮质激素对大鼠肾上腺嗜铬细胞分泌儿茶酚胺的急性效应 |
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| 引用本文： | 刘继红,陈智,尹春萍.糖皮质激素对大鼠肾上腺嗜铬细胞分泌儿茶酚胺的急性效应[J].中华内分泌代谢杂志,2004,20(4):363-364. |
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| 作者姓名： | 刘继红 陈智 尹春萍 |
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| 作者单位： | 1. 430030,武汉,华中科技大学同济医学院附属同济医院泌尿外科
2. 430030,武汉,华中科技大学同济医学院附属同济医院 药学院 |
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| 摘 要： | 利用全细胞膜片钳技术,观察不同浓度地塞米松急性灌洗大鼠肾上腺嗜铬细胞(AMCC)后钙通道电流和烟碱受体通道电流(INIC)的变化,地塞米松对大鼠AMCC的急性作用为明显抑制INIC而对电刺激所诱发的钙通道电流无明显影响,提示糖皮质激素对大鼠AMCC分泌儿茶酚胺的急性效应可能与烟碱受体直接相关。
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| 关 键 词： | 肾上腺髓质 嗜铬细胞 儿茶酚胺 地塞米松 烟碱受体通道电流 钙通道电流 |
| 修稿时间： | 2003年1月9日 |
Acute action of glucocorticoid on catecholamine secretion of adrenal chromaffin cells in rats |
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| LIU Ji-hong,CHEN Zhi,YIN Chun-ping.Acute action of glucocorticoid on catecholamine secretion of adrenal chromaffin cells in rats[J].Chinese Journal of Endocrinology and Metabolism,2004,20(4):363-364. |
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| Authors: | LIU Ji-hong CHEN Zhi YIN Chun-ping |
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| Institution: | LIU Ji-hong~*,CHEN Zhi,YIN Chun-ping. ~*Department of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 |
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| Abstract: | By using the whole-cell clamp-patch technique, the effects of dexamethasone on calcium channel current (Ica) and nicotine receptor channel current (I_(NIC)) were examined. The acute action of glucocorticoid on adrenal medullary chromaffin cell (AMCC) of rats was a significant inhibition of I_(NIC), while no apparent effect was observed on Ica induced by electricity. The results suggest that the acute action of glucocorticoid on catecholamine release in rat AMCC may be directly related to nicotine receptor. |
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| Keywords: | Adrenal medulla Chromaffin cells Catecholamine Dexamethasone Nicotine receptor channel current Calcium channel current |
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